Brivanib Alaninate in Treating Patients With Persistent or Recurrent Cervical Cancer

Phase 2

Completed

Conditions: Cervical Adenocarcinoma
Cervical Adenosquamous Carcinoma
Cervical Squamous Cell Carcinoma, Not Otherwise Specified
Persistent Disease
Recurrent Cervical Carcinoma

Interventions: Drug: Brivanib Alaninate
Other: Laboratory Biomarker Analysis

Registration Number: NCT01267253

Lead Sponsor: Gynecologic Oncology Group

Brief Summary: This phase II trial studies how well brivanib alaninate works in treating patients with cervical cancer that has come back. Brivanib alaninate may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth or by blocking blood flow to the tumor.

Detailed Description: PRIMARY OBJECTIVES:

I. To estimate the proportion of patients with persistent or recurrent cervical cancer, who survive progression-free for at least 6 months and the proportion of patients who have objective tumor response (complete or partial), treated with brivanib (brivanib alaninate).

II. To determine the nature and degree of toxicity of brivanib in this cohort of patients.

SECONDARY OBJECTIVES:

I. To estimate the progression-free survival (PFS) and overall survival (OS) of patients with persistent or recurrent cervical cancer treated with brivanib.

TERTIARY OBJECTIVES:

I. To obtain the serum expression levels of surrogate markers of brivanib effects including angiogenic factors (vascular endothelial growth factor \[VEGF\] and basic fibroblast growth factor \[bFGF\]) and markers of endothelial damage (E-selectin, vascular cell adhesion molecule 1 \[VCAM-1\], and (intercellular adhesion molecule 1 \[ICAM-1\]). (exploratory) II. To determine whether these marker expression levels alone or in combination are associated with response, PFS, or overall survival. (exploratory)

OUTLINE:

Patients receive brivanib alaninate orally (PO) once daily (QD) on days 1-28. Courses repeat every 28 days in the absence of disease progression or unacceptable toxicity.

After completion of study therapy, patients are followed up every 3 months for 2 years and then every 6 months for 3 years.

Recruitment & Eligibility

Status: COMPLETED

Sex: Female

Target Recruitment: 31

Inclusion Criteria

Patients must have persistent or recurrent squamous cell carcinoma, adenosquamous carcinoma, adenocarcinoma, or non-squamous cell carcinoma of the cervix with documented disease progression (disease not amenable to curative therapy); histologic confirmation of the original primary tumor is required via the pathology report
All patients must have measurable disease, defined by Response Evaluation Criteria In Solid Tumors (RECIST 1.1); measurable disease is defined as at least one lesion that can be accurately measured in at least one dimension (longest diameter to be recorded); each lesion must be >= 10 mm when measured by computed tomography (CT), magnetic resonance imaging (MRI) or caliper measurement by clinical exam; or >= 20 mm when measured by chest x-ray; lymph nodes must be >= 15 mm in short axis when measured by CT or MRI
Patient must have at least one ?target lesion? to be used to assess response on this protocol as defined by RECIST 1.1
- Tumors within a previously irradiated field will be designated as ?non-target? lesions unless progression is documented or a biopsy is obtained to confirm persistence at least 90 days following completion of radiation therapy
Patients must not be eligible for a higher priority Gynecologic Oncology Group (GOG) protocol, if one exists
- In general, this would refer to any active GOG phase III protocol or rare tumor protocol for the same patient population
Patients who have received one prior regimen must have a GOG performance status of 0, 1, or 2
- Patients who have received two prior regimens must have a GOG performance status of 0 or 1
Recovery from effects of recent surgery, radiotherapy, or chemotherapy
- Patients should be free of active infection requiring antibiotics (with the exception of uncomplicated urinary tract infection [UTI])
- Any hormonal therapy directed at the malignant tumor must be discontinued at least one week prior to registration
- Any other prior therapy directed at the malignant tumor, including chemotherapy and immunologic agents, must be discontinued at least three weeks prior to registration
- Any prior radiation therapy must be completed at least 4 weeks prior to registration
- At least 4 weeks must have elapsed from the time of any major surgical procedure
Patients must have had one prior systemic chemotherapeutic regimen for management of advanced, metastatic, or recurrent carcinoma of the cervix; chemotherapy administered concurrent with primary radiation (e.g.; weekly cisplatin) is not counted as a systemic chemotherapy regimen for management of advanced, metastatic, or recurrent disease; adjuvant chemotherapy given following the completion of radiation therapy (or concurrent chemotherapy and radiation therapy) is not counted as a systemic chemotherapy regimen for management of advanced, metastatic, or recurrent disease (e.g.; paclitaxel and carboplatin for up to 4 cycles)
Patients are allowed to receive, but are not required to receive, one additional cytotoxic regimen for management of recurrent or persistent disease
Patients must have NOT received any non-cytotoxic (biologic or targeted) agents as part of their primary treatment or for management of recurrent or persistent disease
- Non-cytotoxic (biologic or targeted) agents include (but are not limited to) monoclonal antibodies, cytokines, and small-molecule inhibitors of signal transduction
Absolute neutrophil count (ANC) greater than or equal to 1,500/mcl
Platelets greater than or equal to 100,000/mcl
Hemoglobin >= 9 g/dl
Creatinine less than or equal to 1.5 x institutional upper limit of normal (ULN)
Urinalysis needs to be assessed at baseline and proteinuria must be less than or equal to 2+ by dipstick
- If the urine dipstick is > 2+, a 24-hour protein level can be done, as clinically indicated by the investigator
  - The 24-hour protein level must be less than or equal to 3.5 g/24 hours
Bilirubin less than or equal to 1.5 x ULN
Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) less than or equal to 3 x ULN
Alkaline phosphatase less than or equal to 2.5 x ULN
Albumin greater than or equal to 2.5 g/dl
Neuropathy (sensory and motor) less than or equal to grade 1
Prothrombin time (PT) such that international normalized ratio (INR) is =< 1.5 x ULN; patients on therapeutic warfarin are excluded from trial, anticoagulation with low molecular weight heparin is allowed
Patients must have signed an approved informed consent and authorization permitting release of personal health information
Patients of childbearing potential must have a negative serum pregnancy test performed 48 hours prior to study entry and be practicing an effective form of contraception during the study and for at least 3 months after receiving the final treatment of brivanib
All patients must have a baseline electrocardiogram completed prior to study entry
- Baseline electrocardiogram (ECG) should be repeated if corrected QT interval (QTc) is found to be > 450 msec; QTc must NOT be > 450 msec on both ECGs performed during the same visit

Exclusion Criteria

Patients who have had prior therapy with brivanib or anti-vascular, anti-PDGFR (platelet-derived growth factor receptor) or anti-FGFR (fibroblast growth factor receptor) therapy
Patients with a history of other invasive malignancies, with the exception of non-melanoma skin cancer and other specific malignancies, are excluded if there is any evidence of the other malignancy being present within the last three years; patients are also excluded if their previous cancer treatment contraindicates this protocol therapy
Patients who have received prior radiotherapy to any portion of the abdominal cavity or pelvis OTHER THAN for the treatment of cervical cancer within the last three years are excluded
- Prior radiation for localized cancer of the breast, head and neck, or skin is permitted, provided that it was completed more than three years prior to registration, and the patient remains free of recurrent or metastatic disease
Patients who have received prior chemotherapy for any abdominal or pelvic tumor OTHER THAN for the treatment of cervical cancer within the last three years are excluded
- Patients may have received prior adjuvant chemotherapy for localized breast cancer, provided that it was completed more than three years prior to registration, and that the patient remains free of recurrent or metastatic disease
Patients that are on required chronic anti-platelet therapy (aspirin > 300 mg/day, or clopidogrel greater than or equal to 75 mg/day)
Patients with gastrointestinal bleeding or any other hemorrhage/bleeding event >= grade 3 of the National Cancer Institute (NCI) Common Terminology Criteria for Adverse Events (CTCAE) within 30 days prior to study entry
Patients with a history of poor wound healing, non-healing ulcers, or bone fractures within the last 3 months
Patients with uncontrolled or significant cardiovascular disease including any of the following:
- Myocardial infarction within 12 months
- Uncontrolled angina within 12 months
- Class III-IV New York Heart Association (NYHA) congestive heart failure
- Uncontrolled hypertension despite anti-hypertensive therapy
  - Blood pressure (BP) must be less than or equal to 140/90 at screening
  - Subjects with a history of hypertension who are receiving treatment with calcium channel blockers that are cytochrome P450 family 3, subfamily A, polypeptide 4 (CYP3A4) inhibitors should be changed to an alternative antihypertensive medication before study entry
- History of stroke, transient ischemic attack (TIA), or other central nervous system (CNS) ischemic event
- Cardiac arrhythmias requiring anti-arrhythmic therapy other than beta blockers or digoxin
- Patients must have pre-therapy left ventricular ejection fraction (LVEF) testing and have an ejection fraction >= institutional lower limit of normal (LLN)
- Patients with valvular heart disease >= grade 2
Patients with a serious uncontrolled medical disorder or active infection which would impair the ability of the subject to receive protocol therapy or whose control may be jeopardized by the complications of this therapy
Pre-existing thyroid abnormality with thyroid function that cannot be maintained in the normal range with medication
Patients with hyponatremia (sodium < 130 mEq/L)
Patients with active/known human immunodeficiency virus (HIV), hepatitis B, or hepatitis C; HIV-positive subjects on combination antiretroviral therapy are ineligible
Patients with known brain metastases
Patients who are pregnant or nursing
Patients with inability to swallow tablets or untreated malabsorption syndrome
Patients with baseline serum potassium < 3.5 mmol/L (potassium supplementation may be given to restore the serum potassium above this level prior to entry study)
Patients on therapeutic warfarin anticoagulation are excluded
- Patients converted to anticoagulation with low molecular weight heparin will be allowed provided the patient?s PT is such that INR is =< 1.5 x ULN

Study & Design

Study Type: INTERVENTIONAL

Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Treatment (brivanib alaninate)	Laboratory Biomarker Analysis	Patients receive brivanib alaninate PO QD on days 1-28. Courses repeat every 28 days in the absence of disease progression or unacceptable toxicity.
Treatment (brivanib alaninate)	Brivanib Alaninate	Patients receive brivanib alaninate PO QD on days 1-28. Courses repeat every 28 days in the absence of disease progression or unacceptable toxicity.

Primary Outcome Measures

Name	Time	Method
Objective Tumor Response	Every other cycle for first 6 months; then every 3 months thereafter until disease progression confirmed; and at any other time if clinically indicated based on symptoms or physical signs suggestive of progressive disease.	Proportion of participants with objective tumor response. Objective tumor response is defined as complete or partial tumor response assessed by RECIST 1.1
PFS for at Least 6 Months Without Non-protocol Therapy From Study Entry.	Every other cycle for first 6 months; then every 3 months therafter until disease progression confirmed; and at any other time if cliniclly indicated based on symptoms or physical signs suggestive of progressive disease	Proportion of participants who survive progression-free for at least 6 months without non-protocol therapy from study entry. Progression is assessed by RECIST 1.1.
Adverse Events (Grade 3 or Higher) During Treatment Period	During treatment period and up to 30 days after stopping the study treatment.	Number of participants with a maximum grade of 3 or higher during treatment period. Adverse events are graded and categorized using CTCAE v.4.0

Secondary Outcome Measures

Name	Time	Method
Progression-free Survival	From study entry to time of progression or death, whichever occurs first, up to 5 years of follow-up	Progression-free survival is the period of time from study entry to time of disease progression, death or date of last contact, whichever occurs first. Progression is assessed by RECIST 1.1
Overall Survival	From study entry to time of death or the date of last contact, up to 5 years of follow-up.	Overall survival is defined as the duration of time from study entry to time of death or the date of last contact..

Trial Locations

Locations (43): Smilow Cancer Hospital Care Center at Saint Francis
🇺🇸
Hartford, Connecticut, United States
Beebe Medical Center
🇺🇸
Lewes, Delaware, United States
Christiana Care Health System-Christiana Hospital
🇺🇸
Newark, Delaware, United States
Sarasota Memorial Hospital
🇺🇸
Sarasota, Florida, United States
Cooper Hospital University Medical Center
🇺🇸
Camden, New Jersey, United States
Case Western Reserve University
🇺🇸
Cleveland, Ohio, United States
Saint Vincent Hospital and Health Care Center
🇺🇸
Indianapolis, Indiana, United States
Riverside Methodist Hospital
🇺🇸
Columbus, Ohio, United States
Summa Akron City Hospital/Cooper Cancer Center
🇺🇸
Akron, Ohio, United States
Carolinas Medical Center/Levine Cancer Institute
🇺🇸
Charlotte, North Carolina, United States
West Penn Hospital
🇺🇸
Pittsburgh, Pennsylvania, United States
Baylor All Saints Medical Center at Fort Worth
🇺🇸
Fort Worth, Texas, United States
Women and Infants Hospital
🇺🇸
Providence, Rhode Island, United States
Lyndon Baines Johnson General Hospital
🇺🇸
Houston, Texas, United States
M D Anderson Cancer Center
🇺🇸
Houston, Texas, United States
Virginia Commonwealth University/Massey Cancer Center
🇺🇸
Richmond, Virginia, United States
Providence Saint Joseph Medical Center/Disney Family Cancer Center
🇺🇸
Burbank, California, United States
The Hospital of Central Connecticut
🇺🇸
New Britain, Connecticut, United States
Florida Hospital Orlando
🇺🇸
Orlando, Florida, United States
Memorial Health University Medical Center
🇺🇸
Savannah, Georgia, United States
University of Chicago Comprehensive Cancer Center
🇺🇸
Chicago, Illinois, United States
Saint Mary Mercy Hospital
🇺🇸
Livonia, Michigan, United States
Saint Joseph's Hospital and Medical Center
🇺🇸
Phoenix, Arizona, United States
University of Oklahoma Health Sciences Center
🇺🇸
Oklahoma City, Oklahoma, United States
UCSF Medical Center-Mount Zion
🇺🇸
San Francisco, California, United States
Baystate Medical Center
🇺🇸
Springfield, Massachusetts, United States
Michigan Cancer Research Consortium NCORP
🇺🇸
Ann Arbor, Michigan, United States
Greater Baltimore Medical Center
🇺🇸
Baltimore, Maryland, United States
Rush University Medical Center
🇺🇸
Chicago, Illinois, United States
Kettering Medical Center
🇺🇸
Kettering, Ohio, United States
Abington Memorial Hospital
🇺🇸
Abington, Pennsylvania, United States
Oklahoma Cancer Specialists and Research Institute-Tulsa
🇺🇸
Tulsa, Oklahoma, United States
Saint Joseph Mercy Hospital
🇺🇸
Ann Arbor, Michigan, United States
Sudarshan K Sharma MD Limited-Gynecologic Oncology
🇺🇸
Hinsdale, Illinois, United States
Women's Cancer Center of Nevada
🇺🇸
Las Vegas, Nevada, United States
Union Hospital of Cecil County
🇺🇸
Elkton, Maryland, United States
University of Mississippi Medical Center
🇺🇸
Jackson, Mississippi, United States
University of Wisconsin Hospital and Clinics
🇺🇸
Madison, Wisconsin, United States
CoxHealth South Hospital
🇺🇸
Springfield, Missouri, United States
Lake Huron Medical Center
🇺🇸
Port Huron, Michigan, United States
UH Seidman Cancer Center at Lake Health Mentor Campus
🇺🇸
Mentor, Ohio, United States
Nebraska Methodist Hospital
🇺🇸
Omaha, Nebraska, United States
Saint Joseph Mercy Oakland
🇺🇸
Pontiac, Michigan, United States