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临床试验/NCT04812249
NCT04812249Unknown不适用

Effect of Co-morbidities on the Development of Oral Feeding Ability in Pre-term Infants: a Prospective Study at Neonatology Unit of Assiut University Children Hospital

Assiut University0 个研究点目标入组 160 人开始时间: 2021年5月1日最近更新:
适应症

试验速览

阶段
不适用
入组人数
160
主要终点
The mean post-menstrual age in weeks at the time of starting and achieving full oral feeding will be evaluated

研究概览

简要总结

The aim of this study is to investigate the effect of co-morbidities on the timing of the achievement of full oral feeding in a cohort of pre-term infants and to evaluate their mode of feeding and feeding status at the time of hospital discharge.

详细描述

It is widely acknowledged that pre-term infants frequently experience difficulties in attaining independent oral feeding, thus delaying the achievement of an adequate nutritional status and hospital discharge which - according to the American Academy of Pediatrics- requires the ability to feed exclusively by mouth(1-2) The development of oral feeding ability in pre-term infants is therefore a primary concern for neonatologists.

Because of the immaturity of their body functions and the occurrence of co-morbidities, pre-term infants generally require a period of enteral feeding before they acquire the coordinated sucking ability that allows sufficient milk intake for growth(3) Furthermore, infant sucking skills differ between bottle- and breastfeeding (4), and pre-term infants have been reported to show a weaker and less coordinated suck (5).

Few studies have investigated the timing and effect of co-morbidities on the achievement of independent oral skills. Jadcherla et al. (6) reported that infants born with a gestational age of < 28 weeks showed a significant delay in attaining the transition to oral feeding, but it has also been found that the occurrence of morbidities negatively correlates with postmenstrual age at the time of achieving oral feeding skills (6),(7-8).

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Prospective

入排标准

年龄范围
— 至 1 Day(Child)
性别
All
接受健康志愿者

入选标准

  • A randomised sample of all newborns whose gestational age of < 37 weeks .
  • infants who will be admitted to the NICU of Assiut University Children Hospital between 1 May and 31 October 2021.

排除标准

  • known congenital and/or chromosomal diseases.
  • death during hospitalisation, or transfer to another institution.

结局指标

主要结局

The mean post-menstrual age in weeks at the time of starting and achieving full oral feeding will be evaluated

时间窗: Baseline

Statistical analysis will be made using SPSS version 12 software to assess the outcomes

次要结局

未报告次要终点

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Mohammed Khalaf Ali

Assistant Lecturer

Assiut University

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