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LY4268989 (MORF-057) Co-Administered With Mirikizumab in Adults With Moderately to Severely Active Ulcerative Colitis:

Not Applicable
Not yet recruiting
Conditions
Ulcerative Colitis
Interventions
Drug: LY4268989
Drug: LY4268989 Placebo
Registration Number
NCT07186101
Lead Sponsor
Eli Lilly and Company
Brief Summary

The main purpose of the study is to evaluate the effectiveness and safety of LY4268989 when given with mirikizumab compared to mirikizumab alone in adult participants with moderately to severely active ulcerative colitis (UC).

Study participation will last approximately 114 weeks, including 104 weeks of treatment and may include up to 21 visits.

Detailed Description

Not available

Recruitment & Eligibility

Status
NOT_YET_RECRUITING
Sex
All
Target Recruitment
252
Inclusion Criteria
  • Have had an established diagnosis of ulcerative colitis (UC) of ≥3 months in before baseline, which includes endoscopic evidence of UC and a histopathology report that supports a diagnosis of UC
  • Have moderately to severely active UC as defined by a Modified Mayo Score (mMS) of 5 to 9 with an Endoscopic Score (ES) ≥2 confirmed by central reader and rectal bleeding (RB) ≥1, with endoscopy performed within 14 days before baseline
  • Participants with greater than 8 years of UC symptoms have documented evidence of having had a surveillance colonoscopy within 1 year, or according to local country or regional medical guidelines, to evaluate for polyps, dysplasia, or malignancy, prior to randomization
  • Are up-to-date on colorectal cancer surveillance per local society guidelines
  • Have an inadequate response to, loss of response to, or intolerance to at least 1 of the medications:
  • Conventional-failed participants: Participants who have had an inadequate response to or a loss of response to or are intolerant to at least 1 of the following medications: corticosteroids or immunomodulators (Does not apply to US)

NOTE: After the interim analysis, participants with inadequate response, loss of response, or intolerance to conventional UC therapy without prior exposure to biologics may be enrolled if deemed appropriate (Applies to the US)

  • Advanced therapy-failed participants: Participants who have an inadequate response to or a loss of response to, or are intolerant to advanced therapy for UC, defined as:

    • a biologic or biosimilar medication such as anti-tumor necrosis factor (anti-TNF) antibodies or anti-interleukin antibodies (IL-12/23, or IL-23p19), except for

      • mirikizumab.
    • Janus kinase inhibitors (JAK) such as filgotinib, tofacitinib, or upadacitinib

    • sphingosine 1-phosphate receptor 1 inhibitors (S1PR) such as etrasimod or ozanimod

Exclusion Criteria
  • Have a current diagnosis of

    • Crohn's disease
    • Inflammatory Bowel Disease (IBD) unclassified (formerly known as indeterminate colitis), or
    • primary sclerosing cholangitis
  • Have had or will need bowel resection or intestinal or intra-abdominal surgery

  • Have evidence of toxic megacolon, intra-abdominal abscess, or stricture or stenosis within small bowel or colon that cannot be traversed by a colonoscope or that are symptomatic

  • Have any adenomatous polyp occurring in areas of the colon not involved by colitis, that has not been removed

  • Have a current or recent acute, active infection

Study & Design

Study Type
INTERVENTIONAL
Study Design
PARALLEL
Arm && Interventions
GroupInterventionDescription
LY4268989 + MirikizumabLY4268989LY4268989 administered orally (PO) + Mirikizumab administered intravenously (IV), then subcutaneously (SC). Responders will be re-randomized for Study Period 2.
LY4268989 + MirikizumabMirikizumabLY4268989 administered orally (PO) + Mirikizumab administered intravenously (IV), then subcutaneously (SC). Responders will be re-randomized for Study Period 2.
Mirikizumab + LY4268989 PlaceboMirikizumabMirikizumab administered IV, then SC + LY4268989 placebo administered PO. Responders and Non-responders will re-randomized for Study Period 2.
Mirikizumab + LY4268989 PlaceboLY4268989 PlaceboMirikizumab administered IV, then SC + LY4268989 placebo administered PO. Responders and Non-responders will re-randomized for Study Period 2.
Primary Outcome Measures
NameTimeMethod
Percentage of Participants Who Achieve Clinical Remission with Modified Mayo Score (mMS)Week 12

The mMS is a composite sore reported by participants and physician and is comprised of the following 3 subscores: Stool Frequency (SF); Rectal Bleeding (RB), and Endoscopic Subscore (ES).

Clinical remission (mMS) is defined as:

* SF subscore = 0 or 1 and no greater than baseline

* RB subscore = 0

* Centrally read ES = 0 or 1; score of 1 modified to exclude friability

Secondary Outcome Measures
NameTimeMethod
Percentage of Participants Who Achieve Clinical Response with Modified Mayo Score (mMS)Week 12
Percentage of Participants Who Achieve Endoscopic ImprovementWeek 12
Percentage of Participants Who Achieve Symptomatic RemissionWeek 12
Percentage of Participants Who Achieve Clinical Remission with mMSWeek 24
Percentage of Participants Who Achieve Clinical Response with mMSWeek 24

Trial Locations

Locations (143)

Mayo Clinic in Arizona - Scottsdale

🇺🇸

Scottsdale, Arizona, United States

Clinnova Research - Anaheim

🇺🇸

Anaheim, California, United States

Om Research LLC

🇺🇸

Lancaster, California, United States

Biopharma Informatic, LLC

🇺🇸

Los Angeles, California, United States

Peak Gastroenterology Associates

🇺🇸

Colorado Springs, Colorado, United States

NeoClinical Research

🇺🇸

Hialeah, Florida, United States

Encore Borland-Groover Clinical Research

🇺🇸

Jacksonville, Florida, United States

Clinical Research of Osceola

🇺🇸

Kissimmee, Florida, United States

Florida Research Institute

🇺🇸

Lakewood Rch, Florida, United States

Alliance Medical Research

🇺🇸

Lighthouse PT, Florida, United States

Scroll for more (133 remaining)
Mayo Clinic in Arizona - Scottsdale
🇺🇸Scottsdale, Arizona, United States
Manreet Kaur
Principal Investigator

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