Impact of Insecticide Resistance in Anopheles Arabiensis on the Effectiveness of Malaria Vector Control in Sudan
试验速览
- 阶段
- 4 期
- 入组人数
- 28,000
- 试验地点
- 3
- 主要终点
- Malaria Incidence
研究概览
简要总结
The purpose of the study is to determine whether long lasting insecticidal nets and indoor residual insecticide spraying, alone or in combination, are effective for controlling insecticide resistant anopheles mosquitoes for malaria prevention.
详细描述
The study will assess the impact that insecticide resistance has on the effectiveness of malaria vector control tools LLIN and IRS. This is done by a cluster randomised trials of universal coverage LLINs versus universal coverage LLINs in combination with IRS, with levels of baseline insecticide resistance in the main vector balanced between the two study arms. In each cluster resistance to the insecticide used on LLINs is monitored, and malaria incidence is estimated from cluster specific cohorts of children followed up over the duration of the study. Resistance impact will be assessed from the ratio of incidence rates in clusters with high compared to those with low resistance and from a continuous measure of resistance expressed as percentage loss of mosquito mortality when exposed to insecticide in standardised WHO tests. Resistance mechanisms will be studied in subsets of study clusters.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 6 Months 至 10 Years（Child）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Children older than 6 months and younger than 10 years in approximately 100 randomly selected households in all 140 study clusters selected in the four study areas
排除标准
- •Children living in households within 1 km from the edge of a neighbouring cluster (the buffer zone)
结局指标
主要结局
Malaria Incidence
时间窗: 3 years
Infection with malarial parasites determined by rapid diagnostic tests/microscopy in cohort members who report or have fever (\>37.5C)
次要结局
- Prevalence of P.falciparum Infection(3 years)
- Entomological Innoculation rate(Average for months Sept, Oct, Nov for years 2011, 2012, 2013)
- Frequency of insecticide resistance associated genotypes (kdr) in anopheles arabiensis(Yearly average 2011, 2012, 2013, 2014)