Cell Free DNA in Mature B-cell Lymphoma

Recruiting

• Conditions: Mature B-Cell Lymphoma
• Interventions: Procedure: peripheral blood collection

• Registration Number: NCT04088422
• Lead Sponsor: Ruijin Hospital

Brief Summary

The purpose of this study is to assess whether plasma cell free DNA is an accurate tool that can early and dynamically inform on treatment outcome and an accessible source of tumor DNA to track tumor clonal evolution.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2019-09-11
• Study First Submitted QC: 2019-09-11
• Study First Posted: 2019-09-12
• Study Start: 2022-09-28
• Status Verified: 2023-02
• Last Update Submitted: 2023-02-23
• Last Update Posted: 2023-02-24
• Primary Completion: 2024-12
• Study Completion: 2026-12

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 320

Inclusion Criteria

• Documented diagnosis of mature B-cell tumor according to WHO 2008 criteria
• 18 years or older

Exclusion Criteria

• Chemotherapy before
• Other tumors

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
B-cell lymphoma	peripheral blood collection	-

Primary Outcome Measures

Name	Time	Method
progression free survival	2-year

Secondary Outcome Measures

Name	Time	Method
overall survival	2-year
Complete Response rate	6 weeks after treatment

Trial Locations

Locations (1)

Ruijin hospital; 🇨🇳 Shanghai, Shanghai, China