Maternal Positive Affect Socialization and Child Neural Reward Response
Overview
- Phase
- Not Applicable
- Intervention
- Parent Coaching
- Conditions
- Depression
- Sponsor
- University of Pittsburgh
- Enrollment
- 180
- Locations
- 1
- Primary Endpoint
- Reward Positivity (RewP)
- Status
- Recruiting
- Last Updated
- 3 months ago
Overview
Brief Summary
The goal of this mechanistic clinical trial is to examine whether parent-coaching aimed at increasing child positive affect will increase child neural response to reward. The main questions it aims to answer are:
Aim 1. Characterize child neural reward response and its relation to maternal socialization of positive emotions at baseline in healthy young children.
Aim 2. Evaluate how coaching-related changes in maternal socialization of positive emotion expression contribute to increases in child neural reward response over time.
Aim 3. Examine how maternal socialization of positive emotion expression contributes to increases in child neural reward response in the moment.
Participating mother-child dyads will be randomized to either 3 sessions of parent coaching of child positive affect or 3 sessions of a general parenting support intervention and neural response to reward and affective behavior will be examined pre and post intervention.
Detailed Description
Reward-related brain function is consistently linked to greater motivation, pleasure, and goal-directed behavior and lower risk for depression across the lifespan. Healthy neural reward response supports socioemotional development, particularly during early childhood as self-regulatory skills and child reward-related brain function are rapidly developing in the context of the caregiving environment. Maternal socialization of positive emotion is one important influence on early reward circuitry development. Mothers with depression are more likely to discourage (and less likely to encourage) child positive emotions compared to healthy mothers, which may contribute to early neural reward alterations in their children. Characterizing mechanisms of influence of maternal socialization on child neural reward response and positive emotion during early childhood is a critical window of opportunity when parents have a large influence on child socioemotional development. Importantly, maternal behavior is amenable to change by training parents on emotion coaching, and these maternal behavior changes may result in direct and immediate changes in child neural reward function. Thus, the overarching aim of this proposal is to use a mechanistic trial design to experimentally test the hypothesis that maternal encouragement of child positive emotion will lead to in-vivo increases in child neural reward response. Event-related potentials (ERPs) are uniquely suited to non-invasively assess in-vivo, fast-occurring changes in child reward response during parent-child interactions, including reward positivity (RewP), and the late positive potential (LPP) amplitudes. Toward this aim, the investigators will randomize 180 mothers with clinically significant depression symptoms and their 4- to 6-year-old children (50% female) to receive either 3 control sessions or 3 positive emotion coaching modules from the Parent-Child Interaction Therapy-Emotion Development (PCIT-ED, which trains mothers on how to encourage positive emotion in their young children. Children will complete reward tasks at pre- and post-coaching, while neural reward response is assessed via ERP (RewP and LPP) with their mothers present allowing for in-vivo assessment of maternal behavior. At both timepoints, the investigators will assess child neural reward response and mothers' self-reported maternal socialization behaviors. Understanding how disrupted neural reward responding develops in early childhood is critical for the promotion of child emotional wellness and can be directly used to develop preventive interventions tailored to young children at familial risk for depression.
Investigators
Judith Morgan
Associate Professor
University of Pittsburgh
Eligibility Criteria
Inclusion Criteria
- •for Mothers:
- •Birth mother (biologically female, any gender)
- •Providing regular care for participating child (i.e., at least 50% of time)
- •Elevated, clinically significant levels of depression (16 or higher on CES-D)
Exclusion Criteria
- •for Mothers:
- •Lifetime history of a bipolar disorder
- •Lifetime history of a psychotic disorder
- •Inclusion Criteria for Participating Child:
- •Aged 4-6 years
- •Exclusion Criteria for Participating Child:
- •T-score greater than 63 on the internalizing or externalizing composites of the CBCL
- •Lifetime history of a psychiatric illness
- •Lifetime history of neurodevelopmental disorder
- •Lifetime history of neurological disorder
Arms & Interventions
Parent Coaching
Parents will receive 3 sessions based on PCIT-ED aimed at increasing child positive affect.
Intervention: Parent Coaching
Active Control
Parents will receive 3 sessions based on traditional PCIT providing more general parenting supporting, including basic psychoeducation and parenting skills.
Intervention: Active Control
Outcomes
Primary Outcomes
Reward Positivity (RewP)
Time Frame: From baseline week 1 to final assessment week 5 (week 10 maximum)
The Reward Positivity (RewP) ERP component of the EEG signal is the mean amplitude (μV; microvolt) on gain-loss trials during receipt of reward related feedback in a computerized reward task with higher RewP amplitudes indicating greater reward response (i.e., more favorable outcome).
Secondary Outcomes
- Parent Responses to Child Positive affect Scale (PRCPS)(From baseline week 1 to final assessment week 5 (week 10 maximum))
- Behavioral Coding of Parental Encouragement of Child Positive Emotion(From baseline week 1 to final assessment week 5 (week 10 maximum))
- Late Positive Potential (LPP)(From baseline week 1 to final assessment week 5 (week 10 maximum))