NCT05926518已完成不适用
Evaluation of Anti-Xa Levels With Nadroparin as Thrombosis Prophylaxis in COVID-19 and Non-COVID-19 Patients Admitted at the ICU
Rijnstate Hospital1 个研究点 分布在 1 个国家目标入组 62 人开始时间: 2020年11月1日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 62
- 试验地点
- 1
- 主要终点
- Evaluation of anti-Xa peak level
研究概览
简要总结
Primary objective The objective of this study is to compare anti-Xa levels obtained with a standard high dose thrombosis prophylaxis in COVID-19 intensive care-patients compared with anti-Xa levels obtained with a normal dose thrombosis prophylaxis in non-COVID-19 intensive care patients.
Secondary objectives
- To determine the incidence of anti Xa levels out of range of the established target anti Xa level in both groups.
- To determine the influence of relevant co-variates on the anti-Xa level in the COVID-19 and non-COVID-19 group.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •All COVID-19 patients > 18 years admitted at the ICU using nadroparin in a high thrombosis prophylactic dosage of 1 dd 5700 IU or 2 dd 5700 IU sc
- •All medical non-COVID-19 patients admitted at the ICU using nadroparin in a standard prophylactic dosage of 1 dd 2850 IU sc.
- •Minimum estimated length of stay on the ICU of 4 days
排除标准
- •o (History of) Heparin Induced Thrombocytopenia and Thrombosis
结局指标
主要结局
Evaluation of anti-Xa peak level
时间窗: 2 years
U/ml
次要结局
- Influence of covariates (nadroparin dosage, gender, age, weight, BMI, COVID-19, APACHE IV, vasopressor use, eGFR, fluid balance, CRP) on anti-Xa level(2 years)
- Percentage of anti-Xa levels within target range(2 years)
研究者
研究点 (1)
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