An Exploratory Phase II Study of Neoadjuvant Treatment With AK112 Plus AP Regimen for Operable Locally Advanced Head and Neck Squamous Cell Carcinoma
Overview
- Phase
- Phase 2
- Intervention
- AK112
- Conditions
- Neoadjuvant Therapy of Operable Locally Advanced Head and Neck Squamous Cell Carcinoma
- Sponsor
- Wuhan Union Hospital, China
- Enrollment
- 36
- Primary Endpoint
- EFS
- Status
- Not Yet Recruiting
- Last Updated
- last year
Overview
Brief Summary
This exploratory phase II study is designed to enroll patients with operable locally advanced head and neck squamous cell carcinoma, to observe the efficacy and safety of AK112 combined with chemotherapy as neoadjuvant therapy on them.
Detailed Description
This exploratory phase II study is designed to enroll 36 patients with operable locally advanced head and neck squamous cell carcinoma(defined according to 8th teh edition of AJCC Guideline). The patients are given 3cycles of AK112(20mg/Kg per cycle) combined with AP regimen(platinum based chemotherapy), with a 3-week interval between each cycle (d1,d22,d43). After 3 cycles' therapy, if the volume of primary tumor decreases by over 50%，the range of resection operation will be conducted by the actual range of tumor, or else the surgery will be conducted by the original range of the tumor. The adjuvant radiation therapy would be conducted in 4-6 weeks after the surgery, while the adjuvant therapy of AK112 would be given in 21days after the surgery for 14 cycles. The process will continue until disease progression or uncontrolled toxicity. The primary endpoint is pCR(pathological complete response) and 2y-EFS; the secondary endpoint is MPR(Main pathological response)、ORR(objective response rate)、2y-OS(overall survival)、organ retention rate and safety assessment.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Age 18-70 years, regardless of sex;
- •histological diagnosis of squamous cell carcinoma in oral cavity,oropharynx, hypopharynx or laryngeal;
- •preoperative evaluation turns to be operatable;
- •locally advanced, according to the American Joint Committee on Cancer ( AJCC -RSB- guidelines, 8th edition),HPV status is determined by p16 immunohistochemistry (IHC);
- •Have not received prior treatment for head and neck squamous cell carcinoma;
- •Have at least one evaluable target lesion according to RECIST version 1.1;
- •ECOG physical condition 0-1 point;
- •The function of the major organs is normal, which meets the following criteria(not receiving blood transfusion in 14 days):
- •a. Hb(hemoglobin)≥90g/L:b. ANC(Neutrophils)≥1.5x109/L; c. PLT(platelet)≥80x109／L；
- •The biochemical tests should meet the following criteria:
Exclusion Criteria
- •Previously received immunotherapy with anti-PD-1(programmed cell death receptor-1), anti-PD-L1, anti-PD-L2, anti-CD137, or anti-CTLA-4 antibodies (including ipilimumab) or any other antibody or drug specifically targeting T-cell co-stimulation or immune checkpoint pathways;
- •Previously received prior chemotherapy or antiangiogenic therapy;
- •Received major surgery ≤4 weeks before admission;
- •Carrying any active autoimmune disease or history of autoimmune disease'
- •Previous or concurrent getting cancers (except those that have been cured and have survived cancer-free for more than 5 years, such as skin basal-cell carcinoma, cervical carcinoma in situ, and papillary thyroid cancer) .
- •Uncontrollable clinical symptom or disease of the heart;
- •Within 14 days before the administration of the study drug, subjects who were required to undergo systemic therapy with corticosteroid (\> 10 mg daily prednisone efficacy dose) or other immunosuppressive agents, in the absence of active autoimmune disease, adrenal hormone replacement with inhaled or topical steroids and a therapeutic dose of prednisone \> 10 mg/day was allowed;
- •Active infection requiring treatment;
- •Patients with congenital or acquired immunodeficiency(such as HIV),active hepatitis B (HBV-DNA ≥104 copies/ml or 2000 IU/ml) , or hepatitis C (HCV-RNA was above the lower limit of detection);
- •The patient has received other cancer specialised treatment;
Arms & Interventions
AK112 combined with AP neoadjuvant therapy
Three cycles of AK112 were given before operation every 3 weeks on D 1, D 22 and D 43, while AP regimen was given every 3 weeks on D 1, D 22 and D 43, respectively.
Intervention: AK112
Outcomes
Primary Outcomes
EFS
Time Frame: 2 years
The time between the onset of treatment till disease progression, discontinuation of treatment for any reason, or death
Secondary Outcomes
- MPR(3 cycles of treatment(1.5months))
- pCR(3 cycles of treatment(1.5months))
- OS(2 years)