NCT00264433已完成2 期
An Open-Label Phase 2a Study in Subjects With N-Cadherin Positive, Advanced or Recurrent Solid Tumors to Investigate the Safety and Efficacy of ADH-1 Administered Intravenously as a Single Agent (Adherex Protocol Number AHX-01-201)
Adherex Technologies, Inc.19 个研究点 分布在 2 个国家开始时间: 2005年12月13日最近更新:
适应症
相关药物
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 发起方
- 试验地点
- 19
研究概览
简要总结
N-cadherin, a protein involved in blood vessel cell binding, is increased as cancer progresses, and is on the surface of many tumor cells. ADH-1 blocks N-cadherin. This study will test the safety and effects of ADH-1 in subjects with specific incurable, solid tumors with a protein biomarker called N-cadherin. This study will examine the clinical activity of ADH-1.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Signed written informed consent
- •Male and female patients > or = 18 years of age with a solid tumor(s) refractory to standard curative therapy or for which no curative therapy exists
- •Histologically proven advanced and/or metastatic solid tumor of one of the following histologies:
- •non-small cell lung cancer (squamous or non-squamous histology),
- •gastroesophageal carcinoma (squamous or adenocarcinoma histology),
- •renal cell carcinoma,
- •hepatocellular carcinoma,
- •adrenocortical carcinoma
- •Measurable disease
- •Immunohistochemical evidence of N-cadherin expression (at least 1+ positive) in archived or fresh tumor tissue
- •Adequate performance status and organ function, as evidenced by hematological and biochemical blood testing and electrocardiogram (ECG)
排除标准
- •Receipt of ADH-1 prior to this clinical study
- •Chemotherapy, radiotherapy, or any other investigational drug within 30 days before study entry
- •History of spinal cord compression, or history of primary brain tumor(s) or brain metastases (known or suspected) unless any lesions have completely resolved following appropriate treatment and there has been no recurrence for at least 6 months
- •History of tumors that have shown clinically significant evidence of active bleeding (e.g., gross hemoptysis, hematemesis, hematuria, melena, or bleeding superficial tumor) within 12 weeks before study entry
- •Stroke, major surgery, or other major tissue injury within 30 days before study entry
- •History of:
- •uncontrolled congestive heart failure,
- •coronary artery disease, or life threatening arrhythmias;
- •myocardial infarction less than 12 months prior to study entry;
- •significant ECG abnormalities; or
- •known hypercoagulable states
研究者
研究点 (19)
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