3D Body Surface Modeling for Scoliosis Monitoring

Recruiting

• Conditions: Adolescent Idiopathic Scoliosis

• Registration Number: NCT05697939
• Lead Sponsor: Stanford University

Brief Summary

This is a single center, prospective, non-randomized reproducibility study of the NSite device in patients undergoing evaluation for scoliosis. The NSite device is a pre-market, investigational device. The study will enroll 13 eligible patients, who will be scanned using the NSite device by 3 separate users in order to assess if the device generates similar results across users. This data will be used to support 510(k) submission.

Detailed Description

The primary objective of this study is to validate the reproducibility of device output in multiple users in a clinical setting. Device output will be predicted probability of major curve magnitude (i.e., Cobb angle) greater than or equal to 20 degrees with 95% confidence interval. We will test whether users obtain similar device output when measuring the same participant (at least 2 scans required for analysis). After excluding bad quality scans, the measurements obtained by these different users (at least 2 users after excluding bad scans) on each study participant will then be compared to determine if they are congruent (having overlapping confidence intervals) or different. The percentage of participants for which users generated congruent predicted probabilities will be reported.

The NSite Scoliosis Assessment App is intended as a clinical decision support tool and requires interpretation by the healthcare professional. It is intended for use for children and adolescent patients 10 to 18 years old. It is for use by prescription only. The NSite Scoliosis Assessment App provides a calculated Asymmetry Index for patients with or at risk for scoliosis, which will yield an output of percentage risk of major curve magnitude (i.e., Cobb angle) greater than 20 degrees, with 95% confidence intervals.

Study Timeline

• Study Start: 2020-08-26
• Study First Submitted: 2023-01-14
• Study First Submitted QC: 2023-01-14
• Study First Posted: 2023-01-26
• Status Verified: 2025-03
• Last Update Submitted: 2025-04-15
• Last Update Posted: 2025-04-16
• Primary Completion: 2030-01-01
• Study Completion: 2030-01-01

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 13

Inclusion Criteria

• Ages 10 and 18 years old
• Referred for evaluation of or diagnosed of adolescent idiopathic scoliosis

Exclusion Criteria

• Scoliosis caused by another condition (e.g., secondary scoliosis)
• Parents/guardians unable to consent
• English is not the primary language (to avoid miscommunication)

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Assess the reproducibility of NSite device	Anticipated to take about one month in order to recruit, enroll, and scan 13 patients.	Percentage of scan outputs reproducible. The percentage of scan sets (3 scans for each participant) that have reproducible predicted probabilities for major curve magnitude ≥ 20 degrees. A reproducible output will be defined as a scan set in which all scans have overlapping 95% confidence intervals for the predicted probability of major curve magnitude ≥ 20 degrees.

Secondary Outcome Measures

Name	Time	Method
User Feedback	Anticipated to take about one month in order to recruit, enroll, and scan 13 patients.	User feedback will be collected throughout testing in the form of open-ended comments. These will be collated and reported.

Trial Locations

Locations (1)

Lucille Packard Children's Hospital and Clinics; 🇺🇸 Palo Alto, California, United States