Gastroscopic Esophageal Prick Test in adult Eosinophilic Esophagitis Patients: a pilot study
Completed
- Conditions
- Eosinophilic Esophagitis, allergy, sensitizations, clinical trial, pilot study, dietary treatmentEosinophiele oesofagitis, allergie, sensibilisatie, klinische studie, pilot studie, dieetbehandeling
- Registration Number
- NL-OMON26684
- Lead Sponsor
- Investigator inintiated study, Academic Medical Center Amsterdam
- Brief Summary
Digestive disease week 2017 oral presentation
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 12
Inclusion Criteria
Previous diagnosis of active EoE confirmed by histopathology e.g. presence of >15 eosinophilic granulocytes per high power field (hpf) in mid or proximal esophageal biopsies
-Macroscopic disease remission or with very mild macroscopic abnormalities after four weeks of treatment with an elemental or elimination diet
Exclusion Criteria
-Inability to stop topical corticosteroids
-Inability to stop beta-blockers and ACE inhibitors
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The primary outcome parameters of our study are: (1) visible mucosal changes within 20 minutes after esophageal allergen injections, the acute response, and (2) visible mucosal changes after 24 hours, the delayed response.
- Secondary Outcome Measures
Name Time Method Secondly, we will compare the local sensitization patterns identified through EPT with those identified through SPT and serum allergen specific IgE testing. Finally, we will evaluate whether the allergens that tested positive on EPT were in agreement with the reported implicating foods in patients’ history.