Application in High Risk Groups of Recently Developed Noninvasive Methods in Diagnosing Coronary Heart Disease.A Community Based Study.
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Type 2 Diabetes
- Sponsor
- Norwegian University of Science and Technology
- Enrollment
- 104
- Locations
- 1
- Primary Endpoint
- Prevalence of cardiac abnormalities/disease according to different examination modalities
- Status
- Completed
- Last Updated
- 9 years ago
Overview
Brief Summary
The purpose of this study is to investigate the prevalence of cardiac disease/coronary artery disease and diagnostic yield of different non-invasive methods in patients with type 2 diabetes 40-75 years of age at examination. Exercise tests, Doppler echocardiographic examination with Tissue Velocity Imaging, stress Echocardiography, transthoracic Doppler of coronary arteries with coronary flow reserve, and cardiac MRI with late enhancement at rest, and perfusion after vasodilatation stress will be used in the study. A subpopulation will in addition measure forearm vasodilation(FMD) and CFR before and after 4 months of exercise training.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Type 2 diabetes
- •Age at diagnosis \> 30 years
- •Age at inclusion 40-75 years
Exclusion Criteria
- •Angina pectoris
- •Coronary angiography/stress-test diagnostic of coronary artery disease last 3 years
- •Previous myocardial infarction, coronary bypass operation/PCI or heart failure
- •Clinical indication for stress -testing
- •Active bronchospasm excluding use of adenosine
- •eGFR \< 30 ml/min/m2
- •short estimated life expectancy due to cancer, chronic liver/renal diseases
Outcomes
Primary Outcomes
Prevalence of cardiac abnormalities/disease according to different examination modalities
Time Frame: at primary examination
Secondary Outcomes
- Relationship between CFR in LAD and forearm FMD(4 months)
- Feasibility of transthoracic coronary Doppler examination/Coronary Flow Reserve, and diagnostic yield related to MRI.(at baseline)
- Doppler echocardiographic findings related to clinical, laboratory and MRI findings(at baseline)
- Feasibility of transthoracic coronary Doppler examination/Coronary Flow Reserve, and diagnostic yield related to MRI(4 months)