Outcomes After Visceral Aortic Coral Reef Surgery

Completed

• Conditions: Aortic Coral Reef

• Registration Number: NCT05983510
• Lead Sponsor: University Paul Sabatier of Toulouse

Brief Summary

Coral reef aorta is defined by a calcified stenosis of the visceral aorta which can cause leg claudication, renal failure and visceral ischemia depending the type and localisation of the stenosis.

This pathology is rare and is usually treated by open surgery with aortic endarteriectomy. Little is know about the outcomes after such aggressive surgery with short series and short follow up.

The authors propose a retrospective study from their institution to explore the post operative and long term outcomes after this surgery.

Detailed Description

Coral reef aorta is defined by a calcified stenosis of the visceral aorta which can cause leg claudication, renal failure and visceral ischemia depending the type and localisation of the stenosis.

This pathology is rare and is usually treated by open surgery with aortic endarteriectomy.

Little is known in the literature regarding the outcomes of this aggressive surgery.

The authors propose a retrospective study from their institution describing the type of surgery realised. They describe the post operative outcomes of this surgery in term of cardiologic, respiratory, renal complication a,d surgical complication.

Moreover they follow the patients to present long term outcomes of this pathology with a description of the post operative recurrence of a coral reef, the permeability of the different target vessel and the cardiologic, respiratory and renal evolution of the different patients.

Study Timeline

• Study Start: 2018-01-01
• Primary Completion: 2023-01-01
• Study Completion: 2023-07-01
• Study First Submitted: 2023-07-19
• Status Verified: 2023-08
• Study First Submitted QC: 2023-08-06
• Last Update Submitted: 2023-08-06
• Study First Posted: 2023-08-09
• Last Update Posted: 2023-08-09

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• Coral reef surgery
• Urgent intervention
• Claudication, renal, visceral involvement
• Thoracic aortic cross clamping (above coeliac trunk)

Exclusion Criteria

• "simple" visceral aorto thrombectomy without opening laterally the aorta
• Pregnant

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Reintervention	1 month after surgery	Need of reintervention before discharge
Major adverse cardiac event (MACE)	1 month after surgery	Post operative cardiologic complication

Secondary Outcome Measures

Name	Time	Method
Long term follow up	1 month, 1 year, yearly up to 5 years	Cumulative survival rate
Target vessel patency	1 month, 1 year, yearly up to 5 years	Permeability of the different vessel (renal and visceral arteries) on CT scan or Duplex ultrasound
Kidney function evolution	1 month, 1 year, yearly up to 5 years	glomerular filtration rate evolution,

Trial Locations

Locations (1)

Hostalrich Aurélien; 🇫🇷 Toulouse, France