Improving medication adherence with Treatment Adherence Therapy in patients with Schizophrenia.

Conditions: psychotic disorder
Schizophrenia
10039628

Registration Number: NL-OMON37335

Lead Sponsor: Vrije Universiteit

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Pending

Sex: Not specified

Target Recruitment: 150

Inclusion Criteria

1). diagnosis 'schizophrenia' according DSM-IV criteria
2). current presciption for antipsychotic medication
3). expected to stay on antipsychotic medication for the next 12 months.
4). outpatient and autonomous in collecting and using antipsychotic medication
5). poor medication adherence, defined as using <80% of prescribed antipsychotic medication

Exclusion Criteria

1). Unable to follow TAT due to inadequate mastery of the Dutch language, or severe cognitive impairment.
2). severe substance abuse

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Assessment of main and secondary study parameters will be conducted at<br /><br>baseline, 12 and 24 months after randomization. The time patients spent each<br /><br>assessment is approximately 55 minutes.<br /><br><br /><br>The primary outcome measure is the proportion of non-adherent patients based on<br /><br>the Brief Adherence Rating Scale (BARS). The BARS is a brief<br /><br>clinician-administered adherence assessment (Byerly et al, 2008). The BARS<br /><br>evaluates episodes of missed medication taking in the past month. The score on<br /><br>the BARS represents the proportion of the taken doses to the prescribed doses.<br /><br>Based on a cut-off score of 80% of prescribed medication, patients will be<br /><br>labelled adherent or non-adherent. This is the most frequent used cut-off<br /><br>criterion in adherence studies for patients with schizophrenia (Valenstein et<br /><br>al., 2002).</p><br>

Secondary Outcome Measures