Partial enteral nutrition in acute Severe Ulcerative Colitis

Not Applicable

• Conditions: Health Condition 1: K51- Ulcerative colitis

• Registration Number: CTRI/2022/03/040832
• Lead Sponsor: Postgraduate Institute of Medical Education and Research

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 17 October 2022

Recruitment & Eligibility

• Status: Open to Recruitment
• Sex: Not specified
• Target Recruitment: 0

Inclusion Criteria

Those with acute severe ulcerative colitis diagnosed on the basis of Modified Truelove and Wittââ?¬•s criteria

Exclusion Criteria

Patients who deny consent

Age � 18years

Pregnant and lactating women

Presence of toxic megacolon as defined by transverse colon diameter more than 5.5cm on abdominal X-ray

Infective exacerbation

Presence of dysplasia or any indication for surgery

Patients who are deemed to require surgery in next 48 hours

Diagnosis is uncertain like Crohnââ?¬•s or indeterminate colitis

Disease extent: E1 disease (15cm or less)

Very low BMI ( <15 kg/m2)

Very high risk of refeeding syndrome (prolonged fasting i.e > 3 days OR low energy diet i.e less than 50% of calorie requirement for > 7 days OR dyselectrolytemia in form of serum K of < 3 meq/L or phosphate < 2 mg/dL or Mg < 1.5 mg/dL)

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
eed for second line therapy or colectomy during index admissionTimepoint: 28 days

Secondary Outcome Measures

Name	Time	Method
Changes in C- reactive protein by day 7Timepoint: Day 7;Changes in fecal calprotectin by day 7Timepoint: 7 days;Changes in serum albumin by day 28 <br/ ><br>Timepoint: Day 28;Response at day 3 as defined by Oxford criteriaTimepoint: 3 days