Protocol for The Lipid Registry of Africa (LIPRA)
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 4,000
- 主要终点
- Risk factors prevalence
研究概览
简要总结
The Lipid Registry of Africa (LIPRA) aims to understand why some individuals in Africa experience heart issues at a younger age than others. The study investigates factors causing heart problems in younger adults, particularly acute coronary syndrome (ACS). Acute coronary syndrome (ACS) includes various heart conditions like unstable angina and heart attacks. Researchers from multiple African countries collaborate to gather information from hospitals across the region. They focus on patients under 55 years (men) or 65 years (women) with heart issues.
Additionally, the study wants to compare different groups-men and women, urban and rural residents-to see if there are specific differences in how heart problems develop among them.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- — 至 65 Years（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Individuals diagnosed with premature Acute Coronary Syndrome (ACS) within the defined age range (≤55 years in men and ≤65 years in women).
- •Patients admitted to designated cardiac facilities in Africa (Urban and rural).
- •Diagnosed cases of ST-elevation myocardial infarction (STEMI) or non-ST-elevation myocardial infarction/unstable angina pectoris (NSTEMI/UAP) based on predetermined criteria including symptoms, electrocardiogram (ECG) alterations, and biomarker levels.
- •Patients exhibiting an increase (above the 95th percentile) or decrease in serum troponin levels as per admission standards.
排除标准
- •Individuals outside the defined age range for premature Acute Coronary Syndrome (ACS) diagnosis.
- •Patients not admitted to designated cardiac facilities in Africa.
- •Diagnosed cases not meeting the specified criteria for Acute Coronary Syndrome (ACS) subtypes (STEMI, NSTEMI/UAP) based on symptoms, electrocardiogram (ECG), and biomarker levels.
结局指标
主要结局
Risk factors prevalence
时间窗: Through study completion, an average of 1 year
The prevalence of traditional Cardiovascular (CV) risk factors among African patients with premature Acute Coronary Syndrome (ACS).
次要结局
- Gender Difference in Risk Factors(Through study completion, an average of 1 year)
- Prevalence of Familial Hypercholesterolemia (FH) According to the Dutch Lipid Clinic Network Score (DLCNS)(Through study completion, an average of 1 year)
- Prevalence of the Use of Invasive Strategy Compared to Conservative Strategy for Managing Patients with Acute Coronary Syndrome (ACS) in Africa(Through study completion, an average of 1 year)