Effect of EGDT on Hepatic Perfusion in Patients With Septic Shock
试验速览
- 阶段
- 不适用
- 发起方
- 试验地点
- 1
- 主要终点
- ICG-PDR and R15 before treatment, after EGDT and 24 hours after EGDT.
研究概览
简要总结
To observe the effect of early goal directed therapy (EGDT) on hepatic perfusion in patients with septic shock.
Hypothesis: Hepatic perfusion did not improved after EGDT in patients with septic shock.
详细描述
Objective To observe the effect of early goal directed therapy (EGDT) on hepatic perfusion in patients with septic shock.
Methods A prospective observational study was carried out. The eligible patients were treated with the standard procedure of EGDT. The hemodynamic data were recorded. Oxygen metabolism and hepatic function were monitored. Indocyanine clearance test was applied to detect the hepatic perfusion. Hemodynamics, hepatic perfusion, oxygen metabolism and hepatic function were compared before treatment, after EGDT and 24 hours after EGDT.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients with septic shock
- •at least one of the EGDT criteria not achieved
- •informed consent accepted
排除标准
- •ages below 18 or above 90
- •the time elapsed over 24 hours after onset of septic shock
- •chronic liver disease
- •terminal stage of disease
- •brain death
- •other types of shock
- •brain injury
- •allergic to iodine or indocyanine
结局指标
主要结局
ICG-PDR and R15 before treatment, after EGDT and 24 hours after EGDT.
时间窗: 30 hours
次要结局
- 28 days mortality(28 days)
研究者
Xiaohua Qiu
physician
Zhongda Hospital