TCTR20170222001终止未知
Intrapulmonary Penetration of Sitafloxacin and Treatment Outcomes in Thai Critically Ill Patients with Pneumonia
适应症
试验速览
- 阶段
- 未知
- 状态
- 终止
- 入组人数
- 40
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 Years 至 0 N/A (No limit)（—）
- 性别
- All
入选标准
- •1. aged more than 18 years who compatible with HAP/VAP
- •2. respiratory failure which required mechanical ventilator to maintain oxygen saturation more than 90%
- •3. hemodynamic stable, BP > 90/60
- •4. new or progress of infiltration in chest radiology
- •5. suspected pneumonia caused by A. baumannii, P. aeruginosa, and Extended Spectrum β-Lactamase (ESBL)-Gram negative pathogens, and/or received at least one antibiotics for empirical treatment of hospital-acquired infections.
排除标准
- •1. patients or their authorities refuse to participate in this study
- •2. patients who pregnant
- •3. patients who lived with HIVS
- •4. patients who have history with fluoroquinolone allergy
- •5. patients who has contraindication to receive sitafloxacin
- •6. patients who has contraindication to BAL
- •7. patients who have QT prolongation (> 480 ms)
- •8. patients who have history of recent unstable angina or myocardial infraction, increase ICP
- •9. patients who have bleeding tendency eg. platelet less than 80,000, INR more than 1.3
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