Influence of Lipid-lowering Drugs in Patients Seropositive for HIV With Lipodystrophy in Resting Energy Expenditure and Total Energy Expenditure
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 45
- 主要终点
- Total Energy Expenditure (kcal/d)
研究概览
简要总结
Background: Several studies have reported increased resting energy expenditure (REE) in people living with HIV/AIDS possibly due to changes in body composition that occurs in HIV lipodystrophy syndrome.
The aim of this study was to evaluate the influence of the use of lipid-lowering drugs in resting energy expenditure (REE) and total energy expenditure (TEE) in patients seropositive for HIV in treatment of lipodystrophy.
详细描述
REE was measured by indirect calorimetry.
TEE was measured by doubly labeled water (DLW) technique and an activity monitor based on accelerometry (AM).
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 否
入选标准
- •Use of antiretroviral therapy for at least 4 months
- •A cluster of differentiation 4 (CD4) T-cell count of >200 cells/mm3
- •Use of lipid-lowering drugs for at least 1 month (group HIV-seropositive with lipodystrophy and use of lipid-lowering)
排除标准
- •Signs or symptoms of opportunistic infections
- •Thyroid disease
研究组 & 干预措施
LIPO+HIPO+
HIV-seropositive with lipodystrophy and use of lipid-lowering drugs.
干预措施: use of lipid-lowering drugs. (Drug)
结局指标
主要结局
Total Energy Expenditure (kcal/d)
时间窗: 14 day
Resting Energy Expenditure (kcal/d)
时间窗: 1 day
次要结局
- Correlation between doubly labeled water and accelerometer to measure total energy expenditure (ICC, 95% CI)(14 days)