Prognostic of Dysfunctional Breathing in Long Covid: a Follow up Study

• Conditions: COVID-19; Dysfunctional Breathing

• Registration Number: NCT05217875
• Lead Sponsor: Hôpital du Valais

Brief Summary

Dysfunctional breathing might participate to dyspnoea in long COVID-19. This study investigate the prognosis of patients diagnosed with dysfunctional breathing after SARS-CoV-2 infection in our center.

Detailed Description

Dysfunctional breathing (DB) with or without hyperventilation syndrome (HVS) as diagnosed using cardiopulmonary exercise test (CPET) was recently demonstrated as an important physiopathological mechanism of persistent dyspnoea in long COVID patients \[1\]. DB is characterized by specific ventilation pattern on CPET accompanied by respiratory discomfort and/or dyspnea at exercise \[2\]. Most patients with DB will have undergone some sort a specific physiotherapy retraining \[3\]. However the prognostic and the predictors of persistence/resolution of DB after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection are unknown.

The aim of the study is to determine the prognostic of patients diagnosed with DB after SARS-CoV-2 infection, as well as prognosis factors and predictors of persistence/resolution of DB during a prospective follow up visit.

Study Timeline

• Study Start: 2021-11-01
• Status Verified: 2021-12
• Study First Submitted: 2022-01-31
• Study First Submitted QC: 2022-01-31
• Last Update Submitted: 2022-01-31
• Study First Posted: 2022-02-01
• Last Update Posted: 2022-02-01
• Primary Completion: 2022-06
• Study Completion: 2022-08

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

• patients 14 years or more
• diagnosis of DB after SARS-CoV-2 at our long covid clinic using a combined approach of symptoms and CPET analysis in the hospitals of Sion, Martigny or Rennaz
• Inclusion between November 2020 and until the end of October 2021

Exclusion Criteria

• Refusal to participate
• comorbidities preventing the CPET or PFT to be carried out

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Persistence/resolution of dysfunctional breathing at follow-up visit	6 to 9 monts from diagnosis	defined by persistence/resolution of dyspnea, as compared with patient's baseline (equivalent level of dyspnea as before COVID-19).

Secondary Outcome Measures

Name	Time	Method
Qualitative changes (increase/decrease/no change of DB pattern of CPET)	6 to 9 monts from diagnosis
Change in ETCO2 and PaCO2	6 to 9 monts from diagnosis
Score HADS changes	6 to 9 monts from diagnosis
Change in ventilatory patterns (tidal volume [VT], breathing frequency [BF] at isowork as compared with baseline	6 to 9 monts from diagnosis
Dispersion of VT and BF during the CPET	6 to 9 monts from diagnosis
Score SF-36 changes	6 to 9 monts from diagnosis
Specific symptom scale changes	6 to 9 monts from diagnosis
Specific work capacity changes questions	6 to 9 monts from diagnosis
Post-COVID Functional Status (PCFS) changes	6 to 9 monts from diagnosis

Trial Locations

Locations (1)

Centre hospitalier du valais romand; 🇨🇭 Martigny, Switzerland