Evaluation of a New Clinical Protocol for Dose Selection of Vancomycin for Continuous Infusion in ICU Patients.
Overview
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Karolinska University Hospital
- Enrollment
- 101
- Locations
- 1
- Primary Endpoint
- Time (days) from start of treatment to first measurement of a plasma vancomycin concentration between 20 and 25 mg/mL
Overview
Brief Summary
This observational study prospectively collect data on chosen dosing, renal function, measured plasma concentrations and adherence to the recommended clinical protocl for ICU patients treated with continuous vancomycin infusion.
Study Design
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- 18 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Start of continuous vancomycin infusion during the course of intensive care and at least one measurement of plasma concentration.
Exclusion Criteria
- •Vancomycin treatment within 96 h before admission to the unit.
- •Vancomycin treatment started with intermittent bolus infusions.
Outcomes
Primary Outcomes
Time (days) from start of treatment to first measurement of a plasma vancomycin concentration between 20 and 25 mg/mL
Time Frame: Until the end of treatment or discharge from unit
The title is a full description.
Relationship between time to intended concentration (15-20 mg/L) and adherence to the dosing protocol (% complete adherence).
Time Frame: Until the end of treatment or discharge from unit
For each patient the actually administired dose of vancomycin will be compared to the recommendation in the dosing protocol. The time to the intended concentration will be compared between patients with 100% adherence to the recommendations and for patients with dosing not following the recommendations.
Secondary Outcomes
- Percentage of the total treatment duration with the intended plasma concentration 15-20 mg/L.(Until the end of treatment or discharge from unit)
- Relationship between Percentage of the total treatment duration with the intended plasma concentration (15-20 mg/L) and adherence to the dosing protocol.(Until the end of treatment or discharge from unit)
Investigators
Johan Petersson
Senior ICU Consultant
Karolinska University Hospital