Randomized Control Trials of Panchagavya Ghrita Nasya in Vishada with special reference to Mild to Moderate Depression.

Thepopulation-based study from India to report on depression shows that theprevalence of depression was 15.1%. India is home to an estimated 57 millionpeople (18% of the global estimate) affected by depression. Consideringthe huge burden and impact of depression and its importance as public healthconcern in developing and developed world, the World Health Organizationdeclared depression: Let’s Talk, as the theme of World Health day on April 07,2017 and lead a yearlong campaign on depression domains.There is also a need to study the course of depressive disordersin India so as to determine the need and duration of continuation treatment.The present study Randomized Control Trials will be carried out with aim to evaluate the efficacy of Panchagavya Ghrita Nasya in Vishada with special reference to Mildto Moderate Depression. For present study patients fulfilling the diagnosticcriteria of Mild to ModerateDepression(ICD-10), between the age group of 18 yrs to 50 yrs with irrespectiveof Gender, religions, socioeconomic status etc. Byusing Sample size formula; Sample size found 57, so that 57patients will be taken for study in each group. Total 114 numbers of patientswill be selected and randomly divided into two groups, named as Group-A (TrialGroup) and Group-B (Control Group) with Single Blind. Panchagavya Ghrita Nasya and HingwadiGhrita Nasya will be carried out in Group-A (Trial Group) patients andGroup-B (Control Group) patients respectively. Trial and Control Drugs will be purchase from GMC certifiedpharmacy. Both drugs will be administered through nasal routewith 3ml quantity in each nostril at morning hours continuous for 14 days. AllSOP of Nasya Karma will be strictly followed during and after treatment. All thefindings will be entered in Case Record Form (CRF) and for better understandingtabulation and graphical presentation will be done. Observations will be drawn on Before Treatment (0th day), During Treatment (At 7th day), AfterTreatment (At 14th day) and Weekly Follow-up after completion oftreatment (At 21th day). Result of study will be calculatedstatistically with appropriate statistical method. Resultwill be drawn on basis of Criteria of assessment and Statistical analysis.Discussion will be done on the basis of observations and result obtained duringthe treatment. Summary will be drawn and whole thesis work will be summarized.Conclusion will be draw strictly on basis of statistical Analysis and will beunbiased.