ADenosine Vasodilator Independent Stenosis Evaluation Study (ADVISE)
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Imperial College London
- Enrollment
- 157
- Locations
- 1
- Primary Endpoint
- Correlation and descriptive characteristics between adenosine free measure of stenosis severity and FFR
Study Overview
Brief Summary
Narrowing of coronary arteries interferes with blood flow and can cause chest pain. Cardiologists sometimes quantify the extent of the narrowing by measuring the fractional flow reserve (the ratio of the pressure in the aorta to the pressure downstream of the narrowing under conditions of maximal flow). We propose a new technique based on principles of wave intensity analysis (WIA) to better assess coronary stenosis and the significance of the narrowing without the need for administration of vasodilator agents such as adenosine. This would simplify assessment and improve our ability to advise patients whether stent treatment will help their symptoms.
Study Design
- Study Type
- Observational
- Observational Model
- Other
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- 18 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Patients with coronary stenosis
Exclusion Criteria
- •Patient's with cardiac pacemakers, valvular heart disease, and chronic renal failure
- •Unable to consent
- •Contraindications to adenosine
- •Contraindications to cardiac MRI
Outcomes
Primary Outcomes
Correlation and descriptive characteristics between adenosine free measure of stenosis severity and FFR
Time Frame: Study end
Secondary Outcomes
No secondary outcomes reported