Effect of Omega-3 Supplementation on Serum Level and Gene Expression of IGF-1and IGFBP-3 in Men With Cardiovascular Disease.
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 31
- 试验地点
- 1
- 主要终点
- Serum Total Cholesterol
研究概览
简要总结
The aim of this study is the comparison between the effects of supplementation with omega 3 or placebo for 8 weeks in serum level of IGF-1 and IGFBP-3 and gene expression of IGF-1 in patients with cardiovascular disease.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 45 Years 至 65 Years（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 否
入选标准
- •CVD patients 45- 65 years old, patients with ≥ 50% stenosis in at least one coronary angiogram demonstrated, body mass index in the range 18.5- 35, avoidance of dietary supplements, vitamins and herbal products at least 3 months before and throughout the intervention, willingness to participation,
排除标准
- •people who have used omega 3 supplements in last 3 months, having chronic renal disease , GI disease, hepatobiliary diseases, hematological disorders, hypo- or hyperthyroidism, Smokers
研究组 & 干预措施
CVD, Placebo
patients with cardiovascular disease who receive 4 cap of placebo/day
干预措施: Placebo (Dietary Supplement)
CVD, Omega-3
patients with Cardiovascular disease who receive 4g/d omega-3
干预措施: Omega-3 (Dietary Supplement)
结局指标
主要结局
Serum Total Cholesterol
时间窗: Change from baseline at 2 months
Serum HDL-C
时间窗: Change frome baseline at 2 months
Serum LDL-C
时间窗: Change frome baseline at 2 months
Serum TG
时间窗: Change frome baseline at 2 months
Serum Fasting Blood Sugar(FBS)
时间窗: Change frome baseline at 2 months
Serum Insulin
时间窗: Change frome baseline at 2 months
Serum hsCRP
时间窗: Change frome baseline at 2 months
Serum Insulin Like Growth Factor-1(IGF-1)
时间窗: Change frome baseline at 2 months
Serum IGF binding protein 3(IGFBP-3)
时间窗: Change frome baseline at 2 months
次要结局
- Gene Expression of IGF-1(Change frome baseline at 2 months)
- Gene expression of IGFBP3(change from baseline at 2 months)