Flurbiprofen Axetil for Uterine Contraction Pain
- Registration Number
- NCT00725218
- Lead Sponsor
- Nanjing Medical University
- Brief Summary
Uterine contraction pain is a common problem after abortion. Optimal analgesic for such suffering is still needed to be guaranteed. Flurbiprofen Axetil is a target-distributable non-steroidal anti-inflammatory drug (NSAID) functioning via block the synthesis of prostaglandin E (PGE). The investigators hypothesized that Flurbiprofen Axetil could suppress the uterine contraction pain after abortion effectively.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 97
Inclusion Criteria
- ASA status I-II
- Performing abortion operation (medical- or drug-induced
- Requiring painless abortion
Exclusion Criteria
- < 19yrs, and >= 45yrs
- History of central active drugs administration
- Drug abuse
- Hypertension
- Diabetes
- Any other chronic diseases
- Allergy to the study drugs
- Habit of over-volume alcohol drinking
- Records of history of centrally active drug use and psychiatry
- Any organic disorders
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description 1 Saline Saline 5 ml injection 10 min prior to propofol administration. 2 Flurbiprofen Axetil Flurbiprofen Axetil 50 mg in 5 ml injection 10min prior to propofol administration.
- Primary Outcome Measures
Name Time Method VAS pain scorings At the end of the operation, 0,5,15,30,60min after operation
- Secondary Outcome Measures
Name Time Method Anesthetic consumptions At the end of the operation Overall VAS satisfaction scorings with analgesia At the end of the study Side effects During the whole period of the study Volume of bleeding At the end of the study
Trial Locations
- Locations (1)
Nanjing Maternal and Child Health Care Hospital
🇨🇳Nanjing, Jiangsu, China