KCT0000082已完成未知
Methotrexate Ventriculo-lumbar perfusion chemotherapy for Leptomeningeal carcinomatosis: phase 2 study
ational Cancer Center0 个研究点目标入组 56 人开始时间: 待定最近更新:
适应症
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 发起方
- 入组人数
- 56
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional Study
入排标准
- 年龄范围
- 18(Year) 至 75(Year)（—）
- 性别
- All
入选标准
- •1) diagnosis of leptomeningeal carcinomatosis (LMC) by either CSF cytology or definite MR findings
- •2) at least one symptom of LMC; headache or increased intracranial pressure
- •(> 15cm H2o), hydrocephalus, cranial neuropathy or cauda equine symptoms
- •3) patient agree to the experimental protocol
排除标准
- •1)CSF pathway block on wholspine MRI or RI cisternography,
- •2)Brain space occupying lesion, which could possibly cause herniation
- •3)Hemorrhagic brain metastasis
- •4)More than grade 3 leucopenia (ANC < 1,000) or thrombocytopenia (< 50K)
- •5)Altered mentality as severe as verbal communication is not possible
- •6)Active systemic cancer progression, at which expected survival is less than 2 months.
研究者
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