In-Target study
Not Applicable
- Conditions
- Health Condition 1: J449- Chronic obstructive pulmonary disease, unspecified
- Registration Number
- CTRI/2022/04/041749
- Lead Sponsor
- St Johns Research Institute
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
COPD patients with FEV1/FVC <0.7
Age 45 years to 80 years
both male and female, all BMI categories
Smokers and non-smokers
Exclusion Criteria
History of active cardiovascular disease with surgical intervention
Malignancy, hepatic or renal insufficiency
History of major surgery, anaemia or tuberculosis in previous 6 months
History of injury in past 3 months that significantly affect physical functionality
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Quality of life measured using standard questionnaires, i.e.EuroQol5DL, St George Respiratory Questionnaire (SGRQ)Timepoint: Post intervention measure after completion of 8 weeks intervention. <br/ ><br>Follow up at 16 weeks, 24 weeks and 1 year post intervention
- Secondary Outcome Measures
Name Time Method Pulmonary function: FEV1, FVC, ratio of FEV1/ FVC <br/ ><br>Emphysema and muscle and adipose tissue mass and distribution on L1 and pectoralis (mm) measured by quantitative chest CT <br/ ><br>Biochemical parameters: Blood sugar, lipid profile, urea, creatinine, erythrocyte sedimentation rate (ESR) <br/ ><br>Anthropometric measurements: Height, weight, waist circumference, hip circumference, mid upper arm circumference, calf circumference <br/ ><br>Body composition: % lean mass, appendicular muscle mass, bone density (DEXA) <br/ ><br>Muscle function: handgrip strength, lower limb muscle function (handheld dynamometer, Isokinetic dynamometer) <br/ ><br>Functional capacity: 6 min walk test (6MWT) <br/ ><br>Physical activity level (PAL): PAL questionnaire <br/ ><br>Hospital Anxiety and Depression Scale Questionnaire for mental healthTimepoint: after completion of 8 weeks intervention