Infants Colics : Towards a Migrainous Origin ?

• Conditions: Migraine Equivalents; Colic, Infantile; Migraine
• Interventions: Other: Non interventional study

• Registration Number: NCT03155360
• Lead Sponsor: Central Hospital, Nancy, France

Brief Summary

According to recent studies, we want to find evidences that infant colics could be a episodic symptom associated to migraine as cyclic vomiting syndrome or abdominal migraine are. The main purpose is to compare the presence of colics in infants between 60 days and 180 days of life and the presence of migraine in their parents to determine if colicky children's parents are more migrainous than other parents.

Detailed Description

Recent studies shows that :

* Infants with colics have more probability to become migrainous when they will grow up

* Migrainous children have more colic history in their past

* Migrainous parents have more babies with colics than non-migrainous parents

According to these studies, we want to find othen evidences that infant colics could be a migraine equivalent as cyclic vomiting syndrome or abdominal migraine are. Recently, the international classification of headache disease IIIbeta added in its appendix colics in the episodic symptoms associated to migraine

The main purpose of our study in the pediatric emergency unit of Nancy is to compare the presence of colics in infants and the presence of migraine in their parents to determine if colicky children's parents are more migrainous than other parents. The data collection will be made thanks to a survey which will be completed by the parents.

Study Timeline

• Study First Submitted: 2017-05-15
• Study First Submitted QC: 2017-05-15
• Study First Posted: 2017-05-16
• Study Start: 2017-05-18
• Status Verified: 2017-08
• Last Update Submitted: 2017-08-08
• Last Update Posted: 2017-08-09
• Primary Completion: 2017-11-01
• Study Completion: 2017-11-01

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 300

Inclusion Criteria

• All infants between 60 days and 180 days of life who comes to the Nancy University Hospital pediatric emergency unit

Exclusion Criteria

• Language barrier of parents

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Infant without colics	Non interventional study	-
Infant with colics	Non interventional study	Infants with colics according to Wessel definition : * Recurrent episodes of irritability, fussing or crying from birth to 4 months of age * Episodes last for 3 hours per day ; on 3 days per week ; for 3 weeks * Episodes can not be attributed to another disorder

Primary Outcome Measures

Name	Time	Method
Proportion of real colics according to Wessel definition	At the inclusion
Proportion of migrainous parents	At the inclusion	Proportion of migrainous parents in each group

Secondary Outcome Measures

Name	Time	Method
Age of ending of colics	At the inclusion	average and median age
Proportion of Infant colics according the feeling parents	At the inclusion
Proportion of partenal migraine	At the inclusion
Proportion of real colics according to Wessel definition in the subgroup of parents who report that their child has colic	at the inclusion
Proportion of maternal migraine	At the inclusion
Age of begining of colics	At the inclusion	average and median age

Trial Locations

Locations (1)

Dr BORSA-DORION Anne; 🇫🇷 Nancy, France