Effect of preoperative oral carbohydrate intake and conventional fasting on neutrophil-lymphocyte ratio in patients undergoing modified radical mastectomy: a randomized controlled trial
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 54
- 试验地点
- 1
- 主要终点
- Change in neutrophil to lymphocyte ratio
研究概览
简要总结
This randomized controlled trial aims to compare the effect of preoperative oral carbohydrate intake and conventional fasting on the neutrophil lymphocyte ratio in patients undergoing modified radical mastectomy under general anesthesia. A total of 54 patients will be randomly divided into two groups. The study group will receive 250 milliliters of a carbohydrate rich drink containing maltodextrin two hours before surgery, while the control group will follow conventional overnight fasting. Neutrophil lymphocyte ratio and blood sugar levels will be measured preoperatively and at six and twenty four hours postoperatively. The study seeks to determine whether preoperative carbohydrate intake can attenuate the inflammatory stress response, reduce insulin resistance, and improve metabolic stability compared to prolonged fasting in patients undergoing major breast surgery.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- Investigator Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- Female
入选标准
- •Patients aged between 18 to 60 years of age.
- •Patient undergoing elective modified radical mastectomy under general anaesthesia.
- •American Society of Anaesthesiologist (ASA) grade I, II and III patients.
排除标准
- •BMI more than 30kg per m2 Patient with recurrent CA Breast Patient on Chemotherapy and Immuno-modulator Therapy within 1 month of surgery Patients with Diabetes Mellitus any other infective pathology Patient who failed to complete the oral drinks.
结局指标
主要结局
Change in neutrophil to lymphocyte ratio
时间窗: at six hours and twenty four hours
次要结局
- Change in blood sugar levels(at six hours and twenty four hours)
研究者
DR Rohan Katare
Bharati Vidyapeeth deemed to be University Medical college