The Effect of External Diaphragmatic Pacemaker on the Patients With Chronic Cor Pulmonale
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- cardiopulmonary function
研究概览
简要总结
This study evaluates the effect of external diaphragmatic pacemaker on the patients with chronic cor pulmonale. Half of participants will receive external diaphragmatic pacemaker, while the other half will receive routine therapy.
详细描述
Investigate the effect of external diaphragmatic pacemaker on chronic cor pulmonale, the indicators include: respiratory muscle force, diaphragmatic degree of excursion and thickness, pulmonary artery pressure, respiratory distress, feeling of fatigue and quality of life, pulmonary function,NT-proBNP,PaO2 and PaCO2.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Investigator)
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •diagnosis of chronic cor pulmonale and admit to hospital
排除标准
- •pneumothorax or mediastinal emphysema
- •active tuberculosis
- •install a cardiac pacemaker
- •acute cardiocerebrovascular events: acute myocardial infarction, acute myocarditis, severe arrhythmia, severe cerebrovascular accidents.
- •pregnancies
- •end-stage patients (expected survival time less than 6 months)
研究组 & 干预措施
external diaphragmatic pacemaker group
use the external diaphragmatic pacemakerI 9 counts per minute, with stimulate frequency 40 Hz
干预措施: external diaphragmatic pacemaker group (Device)
control group
No inervention, just receive conventional therapy
结局指标
主要结局
cardiopulmonary function
时间窗: 10 days
six miunte walk test
次要结局
- MIP(10 DAYS)
研究者
Zhang Xiangyu
Director of Intensive care medicine
Tongji University