CTRI/2018/11/016349招募中3 期
Biomarker-based optimization of adjuvant therapy in glioblastoma - BOAT
试验速览
- 阶段
- 3 期
- 状态
- 招募中
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
入选标准
- •1.Newly-diagnosed GBM or variants (WHO grade IV) proven on histopathology of tumor tissues
- •resected at decompressive surgery/biopsy 2. Adults >=18 years of age at time of enrolment 3. Availability of
- •tumor tissues for assessing MGMT methylation status 4. KarnofskyPerformance Status (KPS) >=70 and
- •Neurologic Performance Status (NPS) 0-1 5. Adequate bone marrow reserve (absolute neutrophil count >1500
- •and platelet count >1,00,000) 6. Normal liver and renal function tests 7. Written informed consent
排除标准
- •1. Recurrent/progressive GBM 2. Transformed secondary GBM from a previous lowergrade
- •glioma 3. Diffuse gliomatosis necessitating whole brain irradiation 4. Prior history of any other
- •malignancy 5. Concurrent treatment with any other investigational agent 6. Any inter-current illness that
- •precludes safe administration of TMZ 7. Unwillingness to comply with proposed therapy and/or follow-up
研究者
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