A Tailored Intervention to Prevent Age-Related Declines in Muscle Power and Functional Ability
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Exercise Training
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
- Enrollment
- 80
- Locations
- 1
- Primary Endpoint
- Force at maximal power
- Status
- Completed
- Last Updated
- 4 months ago
Overview
Brief Summary
Preserving functional ability is crucial for healthy aging. Unfortunately, age-related decreases in muscle power often lead to declines in functional ability. As power is the product of force and velocity, decreases in power can originate from changes in muscle force, contraction velocity, or both, varying between individuals. The primary method to prevent functional disability is power-based resistance training. Although training interventions are effective for most older adults, they do not induce substantial improvements in a subset of the population. These inconsistent outcomes may arise from neglecting the observed differences in the force-velocity (F-v) profiles between individuals. Therefore, this study provides a novel approach to resistance exercise, in which exercise dose is tailored according to the individual's F-v profile. The effectiveness of the tailored method will be assessed in a randomized control trial, comparing the effects of an individualized and a non-individualized 12-week training intervention on muscle power parameters and functional ability.
Investigators
Christophe Delecluse
Principal Investigator
Universitaire Ziekenhuizen KU Leuven
Eligibility Criteria
Inclusion Criteria
- •Community-dwelling adults
- •65-80 years old
Exclusion Criteria
- •Systematic engagement in resistance exercise during the past year
- •Unstable cardiovascular disease, neuromuscular disease, acute infection or fever
- •Recent surgery
- •Lower-extremity injuries
- •Low levels of functional ability (i.e., SPPB score ≤ 9)
- •Cognitive malfunctioning (i.e., Mini-Mental State Examination \< 24)
Outcomes
Primary Outcomes
Force at maximal power
Time Frame: Change from baseline in force at maximal power at 12 weeks
Unilateral (dominant leg) force at maximal power production (N) on the pneumatic leg press device (Leg Press Air 400, Keiser, USA). The test protocol consists of 2 sets of 1 repetition with increasing loads (5-10 kg increments), starting at 20% of body mass. When the participants fail to lift a certain load, the load will be decreased by 2.5-5 kg until their one repetition maximum (1-RM) is reached. The duration of the recovery time between sets will be based on the mean velocity in the preceding repetition, with longer rest periods after high-load, low-velocity attempts. Mean velocity of the best trial per load is used to estimate the individual F-v relationship through a linear equation. This F-v relationship will be used to examine the exercise-induced changes in force at maximal power.
Velocity at maximal power
Time Frame: Change from baseline in velocity at maximal power at 12 weeks
Unilateral (dominant leg) velocity at maximal power production (m/s) on the pneumatic leg press device (Leg Press Air 400, Keiser, USA). The test protocol consists of 2 sets of 1 repetition with increasing loads (5-10 kg increments), starting at 20% of body mass. When the participants fail to lift a certain load, the load will be decreased by 2.5-5 kg until their one repetition maximum (1-RM) is reached. The duration of the recovery time between sets will be based on the mean velocity in the preceding repetition, with longer rest periods after high-load, low-velocity attempts. Mean velocity of the best trial per load is used to estimate the individual F-v relationship through a linear equation. This F-v relationship will be used to examine the exercise-induced changes in velocity at maximal power.
Maximal force (F0)
Time Frame: Change from baseline in maximal force at 12 weeks
Unilateral (dominant leg) maximal force production (N) on the pneumatic leg press device (Leg Press Air 400, Keiser, USA). The test protocol consists of 2 sets of 1 repetition with increasing loads (5-10 kg increments), starting at 20% of body mass. When the participants fail to lift a certain load, the load will be decreased by 2.5-5 kg until their one repetition maximum (1-RM) is reached. The duration of the recovery time between sets will be based on the mean velocity in the preceding repetition, with longer rest periods after high-load, low-velocity attempts. Mean velocity of the best trial per load is used to estimate the individual F-v relationship through a linear equation. This F-v relationship will be used to examine the exercise-induced changes in maximal force.
Maximal velocity (V0)
Time Frame: Change from baseline in maximal velocity at 12 weeks
Unilateral (dominant leg) maximal velocity production (m/s) on the pneumatic leg press device (Leg Press Air 400, Keiser, USA). The test protocol consists of 2 sets of 1 repetition with increasing loads (5-10 kg increments), starting at 20% of body mass. When the participants fail to lift a certain load, the load will be decreased by 2.5-5 kg until their one repetition maximum (1-RM) is reached. The duration of the recovery time between sets will be based on the mean velocity in the preceding repetition, with longer rest periods after high-load, low-velocity attempts. Mean velocity of the best trial per load is used to estimate the individual F-v relationship through a linear equation. This F-v relationship will be used to examine the exercise-induced changes in maximal velocity.
Force-velocity slope
Time Frame: Change from baseline in F-v slope at 12 weeks
Unilateral (dominant leg) force-velocity (F-v) slope on the pneumatic leg press device (Leg Press Air 400, Keiser, USA). F-v slope = force (N) as a function of velocity (m/s). The test protocol consists of 2 sets of 1 repetition with increasing loads (5-10 kg increments), starting at 20% of body mass. When the participants fail to lift a certain load, the load will be decreased by 2.5-5 kg until their one repetition maximum (1-RM) is reached. The duration of the recovery time between sets will be based on the mean velocity in the preceding repetition, with longer rest periods after high-load, low-velocity attempts. Mean velocity of the best trial per load is used to estimate the individual F-v relationship through a linear equation. This F-v relationship will be used to examine the exercise-induced changes in slope.
Maximal power (P0)
Time Frame: Change from baseline in maximal power at 12 weeks
Unilateral (dominant leg) maximal power production (Watt) on the pneumatic leg press device (Leg Press Air 400, Keiser, USA). The test protocol consists of 2 sets of 1 repetition with increasing loads (5-10 kg increments), starting at 20% of body mass. When the participants fail to lift a certain load, the load will be decreased by 2.5-5 kg until their one repetition maximum (1-RM) is reached. The duration of the recovery time between sets will be based on the mean velocity in the preceding repetition, with longer rest periods after high-load, low-velocity attempts. Mean velocity of the best trial per load is used to estimate the individual F-v relationship through a linear equation. This F-v relationship will be used to examine the exercise-induced changes in maximal power.
Secondary Outcomes
- Countermovement jump height(Change from baseline in countermovement jump height at 12 weeks)
- Timed up and go(Change from baseline in timed up and go time at 12 weeks)
- Short Physical Performance Battery (SPPB) score(Change from baseline in SPPB test score at 12 weeks)
- Gait speed(Change from baseline in gait speed at 12 weeks)
- 5-repetition sit-to-stand power(Change from baseline in sit-to-stand performance at 12 weeks)
- Stair ascent time(Change from baseline in stair climbing performance at 12 weeks)
- Stair ascent power(Change from baseline in stair climbing performance at 12 weeks)
- Exercise adherence(Total adherence over 12-week period)
- 5-repetition sit-to-stand time(Change from baseline in sit-to-stand performance at 12 weeks)