The Decline in Walking Performance in Adults With Cerebral Palsy - Influence of Performance Fatigability
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 30
- 试验地点
- 2
- 主要终点
- Neuromuscular fatigue
研究概览
简要总结
Due to an early brain injury occurring in antenatal or postnatal, cerebral palsy (CP) causes alteration in motor function with posture and gait disorders. It is commonly observed motor performance degradation during adulthood, and the underlying pathophysiology remains poorly known.
详细描述
One of the hypotheses to explain the decline in walking capacities in adults with CP is their greater fatigability, that could be related to energy overconsumption (due to the specific biomechanical constraints of their walking pattern) and/or the occurrence of early sarcopenia affecting the compensatory muscle mechanisms commonly seen in children to compensate for architectural disorders and posture alterations. To optimize prevention and/or therapy in these patients, it is crucial to better understand the aetiology of fatigability and its role in the decline in walking performance.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Common for CP and healthy volunteers:
- •Capable of walking for six minutes without stopping
- •Capable of consenting to the tests
- •Specific for the CP group
- •GMFCS I or II at age 18
- •Spastic diplegic cerebral palsy
排除标准
- •Counter-indications to the test procedures
- •Mental retardation or intelligence quotient (IQ) below 80
- •Accompanying diseases not allowing for the test setup
- •Major surgeries altering performance in the last six months
- •Injection of botulin altering maximal force production in the last three months
- •Refusing to sign the consent form
结局指标
主要结局
Neuromuscular fatigue
时间窗: Week : 6
Neuromuscular fatigue, defined as the decrease in maximal voluntary force (in % of the resting value) developed in isometric knee extension following a standardized fatigue protocol.
次要结局
- Maximum voluntary force torque measurement of the knee flexor muscles(Week : 2)
- Maximum voluntary force torque measurement of knee extensor muscles(Week : 4)
- VO2max (in mL/min/kg)(Week : 6)
- Measurement of joint amplitude (in °)(Week : 6)
- Evaluation of neuromuscular fatigue(Week : 6)
- Level of voluntary activation measurement(Week : 6)
- Time (in seconds) taken during the 10-meter walk test(Week : 6)
- Walking Quality evaluation(Week : 6)
- Maximum voluntary force torque measurement of the plantar flexor(Week : 2)
- Measurement of passive torque (in Nm)(Week : 6)
- Time (in s) taken in the "Get Up and Go" test(Week : 6)
- The distance covered (in m) in the 6-minute walking test(Week : 6)
- Berg Balance Scale(Week : 6)