Correlation of single-photon emission computed tomography myocardial flow reserve imaging with invasively measured epicardial and microvascular coronary haemodynamics in adults with angina

Abbott Vascular0 个研究点目标入组 40 人开始时间: 2021年12月9日最近更新: 2021年12月13日

试验速览

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•Patients referred for coronary angiography for investigation of ischaemic chest pain. Inclusion criteria for group 1 is that they have normal epicardial vessels (<30% diameter stenosis) who will undergo invasive coronary flow reserve (CFR) and index of microvascular resistance (IMR) at the time of coronary angiogram.
•Inclusion criteria for group 2 is that they have a moderate-severe lesion on coronary angiogram in either the RCA or LAD, who will undergo fractional flow reserve (FFR), CFR and IMR in both the culprit and non-culprit vessel.

•-Patients with a rise in high-sensitivity troponin I in concert with their ischaemic symptoms
•-Pregnant and breastfeeding women, due to the radiation exposure inherent to this study
•-Patients with allergies to iodine contrast
•-Patients with contraindications to adenosine including: asthma/bronchospasm, greater than first degree heart block or sick sinus syndrome without a pacemaker, symptomatic aortic stenosis or hypertrophic cardiomyopathy, hypotension (SBP < 90 mmHg), unstable angina, cerebral ischaemia or current dipyridamole medication use.
•-Patients with previous evidence of myocardial infarction (such as history of STEMI, NSTEMI) or baseline perfusion abnormalities on SPECT to suggest previous myocardial infarction given it may impact the measurements of FFR/CFR/IMR).

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