Effect of Sweetness Intensity of a Sucrose Solution on Blood Glucose Regulation and Energy Intake
- Conditions
- Blood Glucose, LowHunger
- Interventions
- Registration Number
- NCT04991714
- Lead Sponsor
- University of Vienna
- Brief Summary
The aim of the present study is to investigate the influence of the modulation of the sweetness intensity of a carbohydrate (sucrose)-containing solution on metabolic effects, in particular the regulation of blood glucose concentration and regulation of hunger \& satiety.
- Detailed Description
The study is designed as a randomised cross-over intervention study with four interventions. The study investigates the influence of sweetness modulation by Rebaudioside M (sweetness enhancement) and Lactisol (sweetness inhibition) of a 10% sucrose solution, corresponding to the concentration of a regular soft drink, on blood glucose regulation (blood glucose concentration and regulating hormones) in healthy male volunteers. Furthermore, the study assesses ad libitum energy intake, individual feelings of hunger and satiety, metabolic responses to the interventions, and preference for sweet-tasting foods such as sugar and sweeteners. In addition, the participants' individual thresholds for sweet taste, as well as morphological markers for taste sensitivity and body composition will be recorded as potential influencing factors.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Male
- Target Recruitment
- 30
- male
- healthy
- non-smoking
- normal taste responses towards sweet taste
- female
- regular smokers
- disturbed glucose and/or lipid metabolism
- regular intake of medication
- known allergies against one of the test compounds
- ageusia
- alcohol or drug addiction
- intake of antibiotics within the past 2 months
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description Sucrose + Reb M + Lactisole Rebaudioside M 10% sucrose + 60 mg/L Rebaudioside M + 30 mg/ L Lactisole Sucrose + Reb M + Lactisole Sucrose 10% sucrose + 60 mg/L Rebaudioside M + 30 mg/ L Lactisole Sucrose + Reb M Sucrose 10% sucrose + 60 mg/L Rebaudioside M Sucrose + Reb M + Lactisole Lactisole 10% sucrose + 60 mg/L Rebaudioside M + 30 mg/ L Lactisole Sucrose Sucrose 10% solution in water Sucrose + Lactisole Lactisole 10% sucrose + 30 mg/ L Lactisole Sucrose + Lactisole Sucrose 10% sucrose + 30 mg/ L Lactisole Sucrose + Reb M Rebaudioside M 10% sucrose + 60 mg/L Rebaudioside M
- Primary Outcome Measures
Name Time Method Blood glucose concentration over a time span of 120 minutes after drinking the test solution Glucose concentration \[mg/dL\] in plasma samples before, and 15, 30, 60, 90, and 120 minutes after drinking the test solution
GLP-1 concentration over a time span of 120 minutes after drinking the test solution Glucagon-like peptide 1 concentration in plasma samples \[mmol/L\] before, and 15, 30, 60, 90, and 120 minutes after drinking the test solution
GIP-concentration over a time span of 120 minutes after drinking the test solution Gastric inhibitory polypeptide concentration in plasma samples \[mmol/L\] before, and 15, 30, 60, 90, and 120 minutes after drinking the test solution
Insulin concentration over a time span of 120 minutes after drinking the test solution Insulin concentration \[mmol/L\] in plasma samples before, and 15, 30, 60, 90, and 120 minutes after drinking the test solution
- Secondary Outcome Measures
Name Time Method Metabolic changes over a time span of 120 minutes after drinking the test solution Metabolome analysis in plasma samples \[mmol/L\] before, and 15, 30, 60, 90, and 120 minutes after drinking the test solution
Food intake 120 minutes after drinking of the test solution Ad libitum Food intake from a standardized breakfast
Trial Locations
- Locations (1)
Christian Doppler Laboratory for Taste Research
🇦🇹Vienna, Austria