Neutrophil To Lymphocyte Ratio In Under-Five Children With Severe Acute Malnutrition
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 95
- 试验地点
- 1
- 主要终点
- Primary outcome: To compare the NLR between children with good clinical outcome and those with poor clinical outcome.
研究概览
简要总结
Burden of under-nutrition among under-five children in India is still high.Early detection and management of children at high risk can help in improved outcome. Newer hematological indices/ratios are emerging as markers of inflammation/infection such as Neutrophil-to-lymphocyte ratio (NLR) representing both innate as well as adaptive immunity of body through neutrophils and lymphocytes, respectively. NLR has been evaluated in diagnosis of neonatal sepsis, bacterial / viral pneumonias, febrile seizures, acute appendicitis, asthma, pediatric inflammatory bowel disease, and as predictor of outcome in pediatric intensive care units. In various studies it has been found that higher NLR values were associated with poor outcome.Limited literature is available about the status of NLR in children with severe acute malnutrition.We planned this study to find association between hematological indices and the outcome in children with SAM and for this we will include NLR as our primary marker during this study.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 6.00 Month(s) 至 59.00 Month(s)(—)
- 性别
- All
入选标准
- •Children diagnosed with SAM (aged 6month-59month) as per WHO criteria 2013, which is defined as any one of the following 1.weight-for-length/height less than -3SD 2.MUAC less than 11.5 3.Bilateral pitting pedal edema of nutritional origin.
排除标准
- •Children with 1 Known hematological disorders 2.History of blood transfusion in last 4 weeks 3.Taking the any immunosuppressant drugs 4.Immunodeficiency disorder 5.History of antibiotics in last 2 weeks.
结局指标
主要结局
Primary outcome: To compare the NLR between children with good clinical outcome and those with poor clinical outcome.
时间窗: Till discharge
次要结局
- Secondary outcomes:(1. Duration of hospital stay)
研究者
Dr Kajal Makkar
University College of Medical Sciences & GTB Hospital
