Firefighter Thermoregulatory Responses in Active Fire with Betaine Supplementation
- Conditions
- Body Temperature ChangesBody Water DehydrationInflammation
- Interventions
- Dietary Supplement: PlaceboDietary Supplement: Betaine
- Registration Number
- NCT06042270
- Lead Sponsor
- Michael J. Ormsbee
- Brief Summary
The goal of this clinical trial is to compare betaine supplementation to placebo in firefighters undergoing live burn training regarding thermoregulation and inflammation. The main questions it aims to answer are:
* Does betaine supplementation mitigate rises in core temperature during firefighter live burn training?
* Does betaine supplementation decrease inflammation from firefighter training?
* Does betaine supplementation increase total body water stores?
Participants will supplement with betaine for 1 month and complete:
* Total Body Water measures
* Body Composition measures
* Live Burn training with Core Temperature Measurements
* Provide Salivary samples
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 17
- Structural Firefighter
-
• Participants have a cardiometabolic disease for which they take prescribed medications
- Participants consume supplements known to impact hydration status or performance that they are not willing to stop taking for the study
- Participants are pregnant
- Female participants that have irregular menstrual cycles
- Participants are injured and would not be able to fulfill the live burn scenario
- Participants have sickle cell disease
- Participants have experienced heat stroke within the last 2 years
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Placebo Placebo 10 participants will be given rice-flour as a placebo Betaine Betaine 10 participants will be given betaine
- Primary Outcome Measures
Name Time Method Thermoregulation 10 minutes before the live burn, during the ~15 minute live burn, 10, 20, and 30 minutes after the live burn. Core temperature (Degrees C), skin temperature (Degrees C)
Subjective measures immediately before and immediately after the completion of the live burn Visual analog scales will be given to participants for subjective thermal sensation, rate of perceived exertion, and thirst
Stress (enzyme linked immunoassays) before, immediately after, 10 minutes, and 20 minutes after live burn Salivary expression of Testosterone, Cortisol, interleukin-8, and interleukin 6 will be measured.
Sweat Rate immediately before and immediately after the completion of the live burn Changes in body weight in kg will be used to find loss of sweat in L
Stress (respiration efficiency) immediately before and immediately after the completion of the live burn Air tank pounds per square inch (PSI) will be recorded
Sweat Content immediately before and immediately after the completion of the live burn Tegaderm patches will be worn during the live burn to analyze sodium concentration in sweat.
- Secondary Outcome Measures
Name Time Method Chronic Stress (enzyme linked immunoassays) Before supplementation and after 4 weeks of supplementation Saliva will be analyzed for testosterone, cortisol, uric acid, and c-reactive protein
Chronic Stress (vitals) professional firefighters. Before supplementation and after 4 weeks of supplementation Resting blood pressure in mmHg and heart rate in beats per minute will be measured.
Fluid Compartment Volumes (Bioelectrical Impedance Spectrocopy) professional firefighters. Before supplementation and after 4 weeks of supplementation Intracellular fluid volume (L), extracellular fluid volume (L), plasma volume (L), total body water (L)
Trial Locations
- Locations (1)
Institute of Sports Science and Medicine
🇺🇸Tallahassee, Florida, United States