AMT-562 in Patients With Selected Advanced Solid Tumors

Phase 1

Recruiting

• Conditions: Advanced Solid Tumors
• Interventions: Drug: AMT-562

• Registration Number: NCT06199908
• Lead Sponsor: Multitude Therapeutics (Australia) Pty Ltd

Brief Summary

This is a first-in-human, non-randomized, open-label, multicenter Phase 1 study of AMT-562 in patients with advanced solid tumors.

Detailed Description

Not available

Study Timeline

• Status Verified: 2023-12
• Study First Submitted: 2023-12-21
• Study First Submitted QC: 2024-01-08
• Study First Posted: 2024-01-10
• Study Start: 2024-05-20
• Last Update Submitted: 2024-07-24
• Last Update Posted: 2024-07-26
• Primary Completion: 2025-12-31
• Study Completion: 2025-12-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 72

Inclusion Criteria

• 1. Patients must be willing and able to understand and sign the ICF, and to adhere to the study visit schedule and other protocol requirements.
• 2. Age ≥18 years (at the time consent is obtained).
• 3. Patients with histologically confirmed unresectable advanced solid tumor.
• 4. Patients who have undergone at least one systemic therapy and have radiologically or clinically determined progressive disease (PD) during or after most recent line of therapy, and for whom no further standard therapy is available, or who are intolerable to standard therapy.
• 5. Patients must have at least one measurable lesion as per RECIST version 1.1.
• 6. Eastern Cooperative Oncology Group (ECOG) performance status of 0-1.
• 7. Life expectancy ≥ 3 months.
• 8. Patients must have adequate organ function
• 9. Women of child bearing potential (WCBP), defined as a sexually mature woman who has not undergone surgical sterilization or who has not been naturally postmenopausal for at least 12 consecutive months (i.e., who has had menses any time in the preceding 12 consecutive months) must agree to use two effective contraceptive methods while on study treatment and for at least twelve weeks after the last dose of the IMP.
• 10. WCBP must have a negative serum pregnancy test within 7 days prior to first dose of the IMP.
• 11. Male patients must agree to use a latex condom, even if they had a successful vasectomy, while on study treatment and for at least twelve weeks after the last dose of the IMP.
• 12. Male patients must agree not to donate sperm, and female patients must agree not to donate eggs, while on study treatment and for at least 12 weeks after the last dose of the IMP.
• 13. Availability of tumor tissue sample (either an archival specimen or a fresh biopsy material) at screening.

Exclusion Criteria

• 1. Central nervous system (CNS) metastasis.
• 2. Active or chronic skin disorder requiring systemic therapy.
• 3. History of Steven's Johnson's syndrome or toxic epidermal necrolysis syndrome.
• 4. Persistent toxicities from previous systemic anti-neoplastic treatments of Grade >1.
• 5. Systemic anti-neoplastic therapy within five half-lives or 21 days, whichever is shorter, prior to first dose of the IMP.
• 6. Radiotherapy to lung field at a total radiation dose of ≥ 20 Gy within 6 months, wide-field radiotherapy within 28 days.
• 7. Major surgery within 28 days prior to first dose of the IMP, or no recovery from side effects of such intervention.
• 8. Significant cardiac disease.
• 9. Has a history of (non-infectious) interstitial lung disease (ILD)/pneumonitis t.
• 10. History of thromboembolic or cerebrovascular events, including transient ischemic attacks, cerebrovascular accidents, deep vein thrombosis, or pulmonary emboli within six months prior to first dose of the IMP.
• 11. Acute and/or clinically significant bacterial, fungal or viral infection including hepatitis B (HBV), hepatitis C (HCV), known human immunodeficiency virus (HIV).
• 12. Administration of a live vaccine within 28 days prior to the administration of the first dose of the IMP.
• 13. Patients requiring concurrent treatment of strong inhibitors or inducers of cytochrome P450 3A or 1A2 enzyme (CYP3A or CYP1A2) within 2 weeks prior to the first dose and during the study treatment.
• 14. Known or suspected severe allergy/hypersensitivity (resulting in treatment discontinuation) to monoclonal antibodies.
• 15. Known or suspected intolerance to the components of the IMP.
• 16. Concurrent participation in another investigational therapeutic clinical trial.
• 17. Patients with known active alcohol or drug abuse.
• 18. Pregnant or breast-feeding females.
• 19. Mental or medical conditions that prevent the patient from giving informed consent or complying with the trial or other severe acute or chronic medical or psychiatric conditions or laboratory abnormality that may increase the risk associated with the study participation or the IMP administration or may interfere with the interpretation of study results and, in the judgment of the investigator, would make the patient inappropriate for enrolment in this study.
• 20. Prior history of malignancy other than inclusion diagnosis within five years prior to first dose of the IMP.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Arm 1	AMT-562	AMT-562 Dose Escalation

Primary Outcome Measures

Name	Time	Method
DLTs	up to 24 month	Incidence of dose limiting toxicities
AEs	up to 24 month	Type, incidence and severity of Adverse Events
SAEs	up to 24 month	Type, incidence and severity Serious Adverse Events (SAEs)

Secondary Outcome Measures

Name	Time	Method
ADAs	up to 24 month	Specification and quantification of anti-drug antibodies
TTR	up to 24 month	Time to response assessed by the investigator according to RECIST version 1.1
Cmax	up to 24 month	Maximum concentration (Cmax)
AUC	up to 24 month	Area Under the Curve
Tmax	up to 24 month	time to peak drug concentration
ORR	up to 24 month	Overall response rate assessed by the investigator according to RECIST version 1.1
DCR	up to 24 month	Disease control rate assessed by the investigator according to RECIST version 1.1
PFS	up to 24 month	Progression-free survival assessed by the investigator according to RECIST version 1.1
DOR	up to 24 month	Duration of response assessed by the investigator according to RECIST version 1.1
t1/2	up to 24 month	terminal half-life of the ADC, total antibody and free payload

Trial Locations

Locations (2)

Macquarie University Hospital; 🇦🇺 North Ryde, New South Wales, Australia

Cabrini Malvern Hospital; 🇦🇺 Malvern, Victoria, Australia