Topical Cannabidiol Application and Skin Vascular Reactivity
- Registration Number
- NCT05456113
- Lead Sponsor
- Penn State University
- Brief Summary
Cannabidiol, or CBD, is an over-the-counter "nutraceutical" that is more commonly being used by healthy adults for pain management, recovery from strenuous exercise, and general wellness. However, little research exists on the effects of CBD in otherwise healthy individuals. This study uses iontophoresis, a common technique used in physical therapy, to determine the effectiveness of topical CBD in lessening the reflex increased cutaneous vascular conductance response to stimulation of the skin.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- WITHDRAWN
- Sex
- All
- Target Recruitment
- 48
Inclusion Criteria
- Men and women 18 years of age and older
- English speaking
- Non-obese class III, BMI ≤ 39.9
- Normal HbA1C of <6.5%
Exclusion Criteria
- Abnormal resting heart rate (<60 or >100 bpm) or BP (systolic <100 or >129 mmHg, diastolic <60 or >100 mmHg) values
- Rash, skin disease, disorders of pigmentation
- Known skin allergies
- Diabetes
- Nicotine use (e.g. smoking, chewing tobacco, vaping, etc.)
- Illegal drug use
- Recent (within the last 30 days) CBD users either topical or oral
- Allergy or hypersensitivity to investigational agents
- Women who are pregnant or breastfeeding
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description Placebo Cannabidiol Vehicle control, does not contain cannabidiol Cannabidiol Cannabidiol Active ingredient experimental arm, contains full spectrum connabidiol
- Primary Outcome Measures
Name Time Method Cutaneous Vascular Conductance ~5 hours pulse units as measured by laser Doppler flowmetry
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Noll Laboratory
🇺🇸University Park, Pennsylvania, United States