Cannabidiol and Vascular Reactivity to Skin Sensory Nerve Stimulation
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 入组人数
- 48
- 试验地点
- 1
- 主要终点
- Cutaneous Vascular Conductance
研究概览
简要总结
Cannabidiol, or CBD, is an over-the-counter "nutraceutical" that is more commonly being used by healthy adults for pain management, recovery from strenuous exercise, and general wellness. However, little research exists on the effects of CBD in otherwise healthy individuals. This study uses iontophoresis, a common technique used in physical therapy, to determine the effectiveness of topical CBD in lessening the reflex increased cutaneous vascular conductance response to stimulation of the skin.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Men and women 18 years of age and older
- •English speaking
- •Non-obese class III, BMI ≤ 39.9
- •Normal HbA1C of <6.5%
排除标准
- •Abnormal resting heart rate (<60 or >100 bpm) or BP (systolic <100 or >129 mmHg, diastolic <60 or >100 mmHg) values
- •Rash, skin disease, disorders of pigmentation
- •Known skin allergies
- •Nicotine use (e.g. smoking, chewing tobacco, vaping, etc.)
- •Illegal drug use
- •Recent (within the last 30 days) CBD users either topical or oral
- •Allergy or hypersensitivity to investigational agents
- •Women who are pregnant or breastfeeding
研究组 & 干预措施
Placebo
Vehicle control, does not contain cannabidiol
干预措施: Cannabidiol (Biological)
Cannabidiol
Active ingredient experimental arm, contains full spectrum connabidiol
干预措施: Cannabidiol (Biological)
结局指标
主要结局
Cutaneous Vascular Conductance
时间窗: ~5 hours
pulse units as measured by laser Doppler flowmetry
次要结局
未报告次要终点
研究者
Lacy Alexander
Professor of Kinesiology
Penn State University