Sex-dependent Effects of Flavanol Metabolism and Absorption on Vascular Status
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Cardiovascular Diseases
- Sponsor
- Heinrich-Heine University, Duesseldorf
- Enrollment
- 24
- Locations
- 1
- Primary Endpoint
- Absolute change of Flow-mediated Vasodilation (FMD)
- Status
- Completed
- Last Updated
- 11 years ago
Overview
Brief Summary
Epidemiological studies suggest that certain foods rich in flavanols, including cocoa products, red wine, and tea, are associated with decreased cardiovascular mortality and morbidity. Dietary interventional studies have corroborated this finding and showed that flavanols can acutely and after sustained ingestion improve surrogate markers of cardiovascular risk including endothelial function. Endothelial dysfunction is the key event in the development and progression of cardiovascular disease. The aim of the study is to assess sex specific effects of cocoa flavanols on endothelial and vascular function in healthy subjects.
Investigators
Klinik für Kardiologie, Pneumologie und Angiologie
Klinik für Kardiologie, Pneumologie und Angiologie
Heinrich-Heine University, Duesseldorf
Eligibility Criteria
Inclusion Criteria
- •healthy post-menopausal femal subjects (\>50 years)
- •healthy male subjects (\>50 years)
Exclusion Criteria
- •acute inflammation
- •cardiac arrhythmia
- •renal failure
- •heart failure (NYHA II-IV)
- •diabetes mellitus
- •CRP \> 1 mg/dl
- •malignant disease
Outcomes
Primary Outcomes
Absolute change of Flow-mediated Vasodilation (FMD)
Time Frame: 2 hours
Secondary Outcomes
- Pulse wave velocity(2 hours)
- Augmentation index(2 hours)
- Ambulatory blood pressure(2 hours)
- Plasma flavanol metabolites(2 hours)
- laboratory safety parameters(2 hours)