Role of Magnetic Resonance Imaging in the Diagnostic Evaluation of Adnexal Cystic Lesions.
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- Diagnostic accuracy of MRI in characterization of adnexal cystic lesions
研究概览
简要总结
This prospective study aims to evaluate the diagnostic accuracy of magnetic resonance imaging (MRI) in characterizing adnexal cystic lesions and differentiating benign from malignant lesions. MRI findings will be correlated with histopathology, surgical data, laboratory results, or follow-up imaging when surgery is not performed, to improve diagnostic confidence and guide appropriate patient management.
详细描述
Adnexal cystic lesions are commonly encountered in gynecologic imaging and may represent a spectrum of benign and malignant conditions. While ultrasound is the first-line imaging modality due to its accessibility and safety, many adnexal masses remain indeterminate.
Magnetic resonance imaging (MRI) provides superior soft-tissue contrast and multiparametric imaging, including T1-, T2-weighted sequences, diffusion-weighted imaging (DWI), and dynamic contrast-enhanced imaging (DCE), allowing better characterization of adnexal lesions. Features such as solid tissue, papillary projections, thick septa, and restricted diffusion help differentiate malignant from benign lesions.
This prospective study at Sohag University Hospital will include 50 female patients with adnexal cystic lesions detected on ultrasound. MRI findings will be correlated with histopathology, surgical data, laboratory results (CA-125), or follow-up imaging when surgery is not performed. The study aims to assess the diagnostic accuracy of MRI in differentiating benign from malignant adnexal lesions and to improve clinical decision-making regarding patient management.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Female patients of any age with adnexal cystic lesions detected by ultrasound
- •Adnexal lesions that are indeterminate or suspicious on ultrasound
- •Patients who provide written and oral informed consent
排除标准
- •Patients unwilling to participate or complete the study
- •Contraindications to MRI, including claustrophobia, metallic implants, pacemaker, or prosthetic heart valves
研究组 & 干预措施
adnexal cystic lesions cohort
This group consists of female patients of all ages presenting to the Radiology Department at Sohag University Hospital with adnexal cystic lesions detected on ultrasound. Eligible participants have indeterminate or suspicious ultrasound findings and will undergo MRI for further characterization. MRI findings will be correlated with histopathology, surgical data, laboratory results, or follow-up imaging when surgery is not performed.
干预措施: Magnetic Resonance Imaging (Diagnostic Test)
结局指标
主要结局
Diagnostic accuracy of MRI in characterization of adnexal cystic lesions
时间窗: From MRI examination until final diagnosis (surgery, histopathology, or follow-up imaging), up to 6 months
Assessment of the diagnostic performance of magnetic resonance imaging (MRI) in differentiating benign from malignant adnexal cystic lesions, using histopathology, intraoperative findings, or follow-up imaging as the reference standard. Diagnostic accuracy will be expressed in terms of sensitivity, specificity, and predictive values.
次要结局
未报告次要终点
研究者
Mira Noshey Mehawed
resident
Sohag University