Non-invasive Prediction of Esophageal Varices in Liver Cirrhosis: A Multicenter Observational Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 363
- 试验地点
- 17
- 主要终点
- Correlation of biochemical data with esophageal varices in liver cirrhosis
研究概览
简要总结
Esophageal variceal bleeding is one of the most lethal complications of liver cirrhosis. In the early stage of liver cirrhosis, the prediction of esophageal varices is very important for guiding the clinical decision making of primary prophylaxis of variceal bleeding.
详细描述
Esophageal variceal bleeding is one of the most lethal complications of liver cirrhosis. In the early stage of liver cirrhosis, the prediction of esophageal varices is very important for guiding the clinical decision making of primary prophylaxis of variceal bleeding. The investigators' recent systematic review evaluated the diagnostic accuracy of APRI, AAR, FIB-4, FI, King, Lok, Forns, and FibroIndex scores in predicting the presence of esophageal varices in liver cirrhosis. However, their diagnostic accuracy was low to moderate. Further study is warranted to establish a reliable score to predict the presence of high-risk esophageal varice in liver cirrhosis.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Cross Sectional
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •A diagnosis of liver cirrhosis.
- •Age and sex are not limited.
- •Etiology of liver cirrhosis is not limited.
- •Routine laboratory data.
- •Upper gastrointestinal endoscopy.
排除标准
- •Non-cirrhotic portal hypertension.
- •Malignancy.
- •Absent laboratory data.
- •A previous diagnosis of esophageal varices.
- •A previous history of variceal bleeding.
结局指标
主要结局
Correlation of biochemical data with esophageal varices in liver cirrhosis
时间窗: 18 months
The investigators firstly calculated the significant factors associated with the presence of esophageal varices, and then developed a score to predict the presence of esophageal varices in liver cirrhosis.
次要结局
未报告次要终点
研究者
Xingshun Qi
Dr.
General Hospital of Shenyang Military Region