The Moran AMD Genetic Testing Assessment Study

Phase 2

Completed

• Conditions: Age-Related Macular Degeneration; Genetic Testing; Nutritional Biomarkers

• Registration Number: NCT05265624
• Lead Sponsor: Paul S. Bernstein

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2022-2-8
• Last Update Posted: 2 September 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 76

Inclusion Criteria

Inclusion Criteria:<br><br> - Participants must be between 18 and 64 years of age.<br><br> - They must also be Caucasian as this genetic test is only validated in Caucasians.<br><br> - They can have a positive family history of AMD but this is not necessary.<br><br>Exclusion Criteria:<br><br> - Personal history of AMD<br><br> - Non Caucasian<br><br> - Employee of the Moran or other eye care practice (likely to have more knowledge<br> about AMD than a layperson)<br><br> - Personal history of prior genetic testing for AMD risk<br><br> - Anticipated cataract surgery in the upcoming year (can affect Macular Pigment<br> measurement)<br><br> - Major psychiatric disorder

Exclusion Criteria

Not provided

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Change in skin carotenoid status in response to genetic risk disclosure as measured by Reflectance Spectroscopy;Change in skin carotenoid status in response to genetic risk disclosure as measured by Resonance Raman Spectroscopy

Secondary Outcome Measures

Name	Time	Method
Change in ocular carotenoid status in response to genetic risk disclosure as measured by Macular Pigment Optical Volume;Change in ocular carotenoid status in response to genetic risk disclosure as measured by Macular Pigment Optical Density;Chang in serum carotenoid status in response to genetic risk disclosure