Evaluating efficacy of PRF and Chorion membrane in regeneration.

Not yet recruiting

• Conditions: Necrosis of pulp,

• Registration Number: CTRI/2022/04/042051
• Lead Sponsor: Shanmathy B

Brief Summary

This study is a randomized, double blind, parallel arm design comparing the effect of Platelet Rich Fibrin (PRF) and Chorion membrane as a scaffold in apexogenesis using cone beam computed tomography (CBCT) carried out in Tamil Nadu Government Dental College and Hospital among 20 patients of age group 13 to 30 years of both gender with immature necrotic teeth exhibiting radiographic evidence of open apex. The primary outcome being clinical evaluation of positive pulp response, absence of mobility, pain, tenderness to percussion and reduction of periodontal probing depth. Secondary outcome being radiographic evidence of increase in root length, dentin wall thickness and narrowing of canal space, root development and apical end closure at end of 3,6,9,12,15,18 months.

Detailed Description

Not available

Study Timeline

• Study Start: 2022-04-05
• Last Update Posted: 2022-04-13

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

Patients with no systemic disease, Periodontally healthy individuals, Patients willing for voluntary participation and have signed the informed consent, Patents with good oral hygiene Patients with necrotic immature teeth exhibiting radiographic evidence of open apex without periapical pathology or periapical pathology (<_10mm).

Exclusion Criteria

Patients who are allergic to Ciprofloxacin , Metronidazole or Minocycline, Patient with known systemic diseases, Teeth not conducive for rubber dam isolation, Grossly decayed or fractured teeth, Teeth with periapical radiolucency >10mm, Teeth with internal or External root resorption, Periodontally compromised teeth,Patients with bleeding disorders,Platelet count < 1,50,000/mm3, Pregnant women in view of requirements for radiographs.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Clinical ssessment of positive pulp response, abscence of mobility, pain , tenderness	3,6,9,12,15,18 months
to percussion and reduction of periodontal probing depth	3,6,9,12,15,18 months

Secondary Outcome Measures

Name	Time	Method
Radiographic assessment of increase in root length , dentin wall thickness and narrowing of	canal space, root development and apical end closure

Trial Locations

Locations (1)

Tamil Nadu Government Dental College and Hospital; 🇮🇳 Chennai, TAMIL NADU, India

Tamil Nadu Government Dental College and Hospital

🇮🇳Chennai, TAMIL NADU, India

Shanmathy B

Principal investigator

8680809114

shanmathy2921@gmail.com