Treatment of severe immune thrombocytopenia with hormone resistance by combination of traditional Chinese and Western Medicine
- Conditions
- Immune thrombocytopenia
- Registration Number
- ITMCTR2000003847
- Lead Sponsor
- Shanghai Hospital of Traditional Chinese Medicine
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- Not specified
(1) Aged 18-80 years old male and female;
(2) Patients with ITP who were treated with glucocorticoid for more than 4 weeks met the diagnostic standard of Chinese expert consensus on diagnosis and treatment of adult primary immune thrombocytopenia (Revised Edition) (2018), and TCM syndrome differentiation belongs to Qi and yin deficiency type;
(3) Two consecutive platelet tests (not detected in the same day) <= 20 x 10^9/L;
(4) Those who voluntarily sign informed consent.
(1) Although it meets the diagnostic criteria of Western medicine, TCM syndrome is not Yin deficiency type;
(2) Patients with history of thrombosis;
(3) HBV, HCV, HIV carriers or patients;
(4) Allergic constitution or allergic to a variety of drugs;
(5) Pregnant or lactating women;
(6) Patients with a history of mental illness;
(7) Suspected or confirmed history of alcohol and drug abuse;
(8) Severe abnormal function of heart, lung, liver and kidney;
(9) Severe or uncontrollable infection;
(10) Those who took other traditional Chinese medicine or participated in other clinical trials in recent 4 weeks;
(11) Any other circumstances in which the investigator believes that the patient should not participate in this study.
Study & Design
- Study Type
- Interventional study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Bone marrow examination;routine blood test;
- Secondary Outcome Measures
Name Time Method Expression of P-gp in CD19+, CD4+;