Effect of TCI Propofol on Liver Transplant (TCI) Propofol on Intra-operative Usage of Vasopressors in Liver Transplant Recipients.
- Conditions
- Liver Transplant Recipients
- Interventions
- Drug: Target control infusion propofol
- Registration Number
- NCT06418893
- Lead Sponsor
- Institute of Liver and Biliary Sciences, India
- Brief Summary
Both isoflurane and propofol are being used to give anaesthesia for living donor liver transplant in our institute. Propofol when compared to isoflurane has advantages like early awakening from anaesthesia, reduced nausea, vomiting in the postoperative period. Propofol also has antioxidant properties. Because of its antioxidant properties propofol may have a protective effect against oxidative stress and ischemia reperfusion injury in major organs during liver transplant surgery. However, there are no studies showing the effect of isoflurane and propofol on Intraoperative hemodynamics and postoperative liver and kidney functions.Thus, we are conducting this study to know the effect of these agents on intraoperative hemodynamics and postoperative liver and kidney function.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 60
-Above 18 years of age who will undergo living donor liver transplant
Refusal to consent
- Acute liver failure, Acute on chronic liver failure
- Allergic to propofol or any component of propofol
- Patients with pre existing cardiac dysfunction and cardiomyopathy
- Patients with pre existing renal dysfunction/ deranged RFTs preoperatively
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Isoflurane Inhalational isoflurane Drug- Isoflurane Dosage form- Inhalational, 1-2% Frequency- Continuously Duration- Throughout Intraoperative period Propofol Target control infusion propofol Drug- Propofol Dosage form- Intravenously, 2.5 mcg/ml target plasma concentration Frequency- Continuously Duration- Throughout Intraoperative period
- Primary Outcome Measures
Name Time Method Comparison of total Noradrenaline and vasopressin requirement between isoflurane and TCI propofol group in Living donor liver transplant recipients intraoperatively. INTRAOPERATIVELY TCI propofol will provide more stable hemodynamics
- Secondary Outcome Measures
Name Time Method To compare between the two groups cardiac output during different phases of liver transplant recorded every 15 minutes INTRAOPERATIVELY AT 15 MINUTES INTERVAL Peak dose of nordrenaline and vasopressin during different phases of liver transplant intraoperatively Intraoperatively Postoperative Liver function tests ie Bilirubin and albumin at 12, 24, 72 hours and day 7 postoperatively Total vasopressor requirement during reperfusion Intraoperative Postoperative Liver function tests ie GGT at 12, 24, 72 hours and day 7 postoperatively Postoperative Liver function tests ie platelet count at 12, 24, 72 hours and day 7 postoperatively To compare between the two groups mean systemic vascular resistance during different phases of liver transplant recorded every 15 minutes INTRAOPERATIVELY AT 15 MINUTES INTERVAL QTc interval between the two groups during different phases of liver transplant measured every 15 minutes Intraoperatively every 15 mins Postoperative coagulation profile at 12, 24, 72 hours and day 7 postoperatively To compare between the two groups mean arterial pressure during different phases of liver transplant recorded every 15 minutes INTRAOPERATIVELY AT 15 MINUTES INTERVAL Postoperative Liver function tests ie AST and ALT at 12, 24, 72 hours and day 7 postoperatively Postoperative Renal function tests i.e. Blood urea and S.creatinine levels at12, 24, 72 hours and day7 postoperatively Peak lactate levels intraoperatively Intraoperatively
Trial Locations
- Locations (1)
Institute of liver and biliary sciences
🇮🇳Delhi, India