Muscle Anabolic Response to Β2-adrenergic Stimulation with Increased Amino Acid Availability.

Not Applicable

Not yet recruiting

• Conditions: Healthy
• Interventions: Drug: Salmeterol + amino acid availability; Drug: Salmeterol + placebo; Drug: Placebo + placebo

• Registration Number: NCT06654986
• Lead Sponsor: University of Copenhagen

Brief Summary

The purpose of the project is to investigate the effect of amino acid availability on the muscle anabolic response to beta2-adrenergic stimulation in young healthy men and women.

Detailed Description

Not available

Study Timeline

• Status Verified: 2024-10
• Study First Submitted: 2024-10-22
• Study First Submitted QC: 2024-10-22
• Last Update Submitted: 2024-10-22
• Study First Posted: 2024-10-23
• Last Update Posted: 2024-10-23
• Study Start: 2024-11-01
• Primary Completion: 2026-12-18
• Study Completion: 2026-12-18

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 36

Inclusion Criteria

• Age 18-40
• Physically active >5 hours a week
• Maximum oxygen uptake classified as high or very high

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Exclusion Criteria

• Active smoker currently or within the past 5 years
• Regular intake of medication deemed by the responsible study physician to affect the test parameters (hormonal contraception is accepted for women)
• Chronic or acute illness deemed by the responsible study physician to affect the test parameters
• Deviation from the study protocol
• Lean mass index >21 kg/m²
• Pregnancy
• Smoker
• Blood donation during the past 3 months

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Salmeterol + amino acid availability	Salmeterol + amino acid availability	The participants will be administered salmeterol from an inhaler device and amino acid availability (protein powder in a shaker) daily during a 6-week intervention.
Salmeterol + placebo	Salmeterol + placebo	The participants will be administered salmeterol from an inhaler device. Furthermore they will be administered placebo (carbo fuel in a shaker) daily during a 6-week intervention.
Placebo + placebo	Placebo + placebo	The participants will be administered placebo from an inhaler device. Furthermore they will be administered placebo (carbo fuel in a shaker) daily during a 6-week intervention.

Primary Outcome Measures

Name	Time	Method
Skeletal muscle hypertrophy	Through study completion, an average on 7 weeks	Muscle hypertrophy measured using Dual-energy X-ray Absorptiometry (DXA).

Secondary Outcome Measures

Name	Time	Method
Quadriceps strength	Through study completion, an average on 7 weeks	Maksimal torque (Nm) achieved during isometric contraction
Power output during sprint testing	Through study completion, an average on 7 weeks	Power output measured in Watts during a sprint on a bike ergometer
Power output during time trial	Through study completion, an average on 7 weeks	Mean power output measured in Watts during a time trial on a bike ergometer

Trial Locations

Locations (1)

August Krogh Building; 🇩🇰 Copenhagen, Denmark