Identifying a blood test to predict risk of deterioration of brain haemorrhage
Completed
- Conditions
- Intracerebral haemorrhage (haemorrhagic stroke)Circulatory System
- Registration Number
- ISRCTN90048218
- Lead Sponsor
- niversity of Manchester
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 40
Inclusion Criteria
1. Diagnosis of primary ICH confirmed by CT brain scan
2. Ability to collect research blood sample within 3 h of symptom onset
3. Likely to survive beyond 24 h (e.g. GCS > 5)
4. ICH not felt to be secondary to an underling structural abnormality (vascular malformation, aneurysm, tumour) or trauma.
Exclusion Criteria
1. Under 18
2. End of life (not expected to survive passed 24 h
3. Other concomitant condition
4. Participation in a CTIMP
5. Pregnancy
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Identification of novel biomarkers for risk of early haematoma expansion after ICH and identification of a proteomic profile of plasma in hyperacute ICH patients who progress to haematoma expansion. This will be measured by analysis inflammatory biomarkers and proteomic profile of the baseline blood sample (taken within 3 hours of symptom onset).
- Secondary Outcome Measures
Name Time Method