Parkinsonism-Related Oscillations in the Cortico-Basal Ganglia-Thalamic Network During Movement: Beyond the Frequency Range
- Conditions
- Parkinson DiseaseHypokinesiaHyperkinesis
- Interventions
- Other: Electrophysiological recordings
- Registration Number
- NCT06438419
- Lead Sponsor
- University Hospital, Bordeaux
- Brief Summary
Expression of hypokinetic and hyperkinetic motor symptoms in Parkinson's disease (PD) is associated with pathological synchronous oscillations of neuronal activity (local field potential/LFP) in the cortico-subcortical network with a wide frequency range. In the present project, we propose to study cortico-subcortical oscillations and their synchronization in patients operated for PD (subthalamic deep brain stimulation (STN-DBS)) during distinct pharmacological and stimulation conditions (hypokinetic and hyperkinetic), using a simple motor task.
- Detailed Description
To define the link between the characteristics of neuronal oscillations (frequency, amplitude, phase relationship) within the cortico-subcortical network and the movement, we designed a simple motor task of gripping/pulling a lever. The LFPs will be collected at the cortical and subcortical levels (STN) during the motor task using a high-resolution EEG (HR-EEG) and the Percept™ system (Medtronic). Recordings will be realized in four conditions: without pharmacological treatment and without stimulation (Off condition), without pharmacological treatment and during stimulation (DBS condition), during pharmacological treatment and without stimulation (DOPA condition) and during pharmacological treatment and stimulation (DOPA+DBS condition).
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 20
- Male or Female
- 18 to 75 years-old
- With idiopathic Parkinson's disease
- Having a STN-DBS with a PERCEPT™ for less than a year or being candidate for STN-DBS with the PERCEPT™ device (first-implantation)
- Able to perform the simple motor task
- Patients covered by a health insurance scheme
- Giving free, informed, written consent signed by the participant and the investigator.
- Be incapable of giving consent personally.
- Be subject to a legal protection measure (curatorship, guardianship) or be placed under judicial protection.
- Being pregnant or breastfeeding
- Present a serious and/or decompensated somatic or psychiatric illness.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description Recruited patient Electrophysiological recordings Patient with idiopathic Parkinson's disease and having a STN DBS with a PERCEPT™ for less than a year or being candidate for subthalamic nucleus deep brain stimulation with the PERCEPT™ device (first-implantation)
- Primary Outcome Measures
Name Time Method Cortico-subcortical electrophysiological coherence At inclusion (Day 0) Statistically significant difference in the cortico-subcortical electrophysiological coherence value between a movement performed in hypokinetic condition and a movement performed in hyperkinetic condition
- Secondary Outcome Measures
Name Time Method Spectral signal power At inclusion (Day 0) Demonstration of a significant difference in spectral signal power between movement in hypokinetic and hyperkinetic conditions.
Effect of STN-DBS on spectral signal power At inclusion (Day 0) Demonstration of a significant effect of STN-DBS on spectral signal power and cortico-subcortical synchronization during movement in hypokinetic or hyperkinetic conditions
Correlation between semiological characteristics At inclusion (Day 0) Demonstration of a statistical correlation between semiological characteristics (hypo- and hyperkinesia, movement parameters (reaction time and movement time)) and electrophysiological characteristics.
Trial Locations
- Locations (1)
Bordeaux University Hospital
🇫🇷Bordeaux, France